Genetic perturbation of AMP biosynthesis extends lifespan and restores metabolic health in a naturally short-lived vertebrate
…, A Oron-Gottesman, M Smirnov, K Shapira, A Velan… - Developmental Cell, 2023 - cell.com
During aging, the loss of metabolic homeostasis drives a myriad of pathologies. A central
regulator of cellular energy, the AMP-activated protein kinase (AMPK), orchestrates organismal …
regulator of cellular energy, the AMP-activated protein kinase (AMPK), orchestrates organismal …
Laboratory Diagnosis of 37 Cases of Bartonella Endocarditis Based on Enzyme Immunoassay and Real-Time PCR
…, Y Maor, EA Katchman, A Treves, A Velan… - Journal of clinical …, 2021 - Am Soc Microbiol
Bartonella spp., mostly Bartonella quintana and B. henselae , are a common cause of
culture-negative endocarditis. Serology using immunofluorescence assay (IFA) and PCR …
culture-negative endocarditis. Serology using immunofluorescence assay (IFA) and PCR …
[HTML][HTML] Melanocortin receptor 1 and black pigmentation in the Japanese ornamental carp (Cyprinus carpio var. Koi)
Colors and their patterns are fascinating phenotypes with great importance for fitness under
natural conditions. For this reason and because pigmentation is associated with diseases, …
natural conditions. For this reason and because pigmentation is associated with diseases, …
Comparative time-course study on pituitary and branchial response to salinity challenge in Mozambique tilapia (Oreochromis mossambicus) and Nile tilapia (O …
The physiological response of Mozambique and Nile tilapia transferred from fresh to brackish
(15 ppt) water was compared during a one-week time course. Response in the pituitary …
(15 ppt) water was compared during a one-week time course. Response in the pituitary …
[HTML][HTML] Association between polymorphism in the Prolactin I promoter and growth of tilapia in saline-water
Tilapias are a group of species with a variable tolerance to high salinity, which are cultured
worldwide in fresh, brackish and seawater. Prolactin I (PRL I) is known as a key hormone in …
worldwide in fresh, brackish and seawater. Prolactin I (PRL I) is known as a key hormone in …
Improving salinity tolerance in tilapias: a review.
With increasing scarcity of fresh water available for aquaculture, especially in arid regions,
development of tilapias that tolerate high salinity would increase fish (and hence, animal …
development of tilapias that tolerate high salinity would increase fish (and hence, animal …
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic …
…, M Leitner, Y Segall, N Ariel, S Cohen, B Velan… - Journal of Biological …, 1993 - ASBMB
Substrate specificity determinants of human acetylcholinesterase (HuAChE) were identified
by combination of molecular modeling and kinetic studies with enzymes mutated in residues …
by combination of molecular modeling and kinetic studies with enzymes mutated in residues …
Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II
Structures of recombinant wild-type human acetylcholinesterase and of its E202Q mutant as
complexes with fasciculin-II, a `three-finger' polypeptide toxin purified from the venom of the …
complexes with fasciculin-II, a `three-finger' polypeptide toxin purified from the venom of the …
Sex-specific regulation of metabolic health and vertebrate lifespan by AMP biosynthesis
…, K Shapira, A Oron-Gottesman, T Levy, A Velan… - Biorxiv, 2022 - biorxiv.org
The loss of energy homeostasis seen during aging, is causally linked to multiple age-related
pathologies. The AMP-activated protein kinase (AMPK) directly senses cellular energy …
pathologies. The AMP-activated protein kinase (AMPK) directly senses cellular energy …
[HTML][HTML] Acetylcholinesterase peripheral anionic site degeneracy conferred by amino acid arrays sharing a common core.
…, A Bromberg, D Marcus, A Lazar, B Velan… - Journal of Biological …, 1994 - Elsevier
Several of the residues constituting the peripheral anionic site (PAS) in human acetylcholinesterase
(HuAChE) were identified by a combination of kinetic studies with 19 single and …
(HuAChE) were identified by a combination of kinetic studies with 19 single and …