[PDF][PDF] A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping
We use in situ Hi-C to probe the 3D architecture of genomes, constructing haploid and diploid
maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion …
maps of nine cell types. The densest, in human lymphoblastoid cells, contains 4.9 billion …
[PDF][PDF] Cohesin loss eliminates all loop domains
The human genome folds to create thousands of intervals, called "contact domains," that
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …
exhibit enhanced contact frequency within themselves. "Loop domains" form because of …
De novo assembly of the Aedes aegypti genome using Hi-C yields chromosome-length scaffolds
The Zika outbreak, spread by the Aedes aegypti mosquito, highlights the need to create high-quality
assemblies of large genomes in a rapid and cost-effective way. Here we combine Hi-…
assemblies of large genomes in a rapid and cost-effective way. Here we combine Hi-…
Genome sequence of Halobacterium species NRC-1
…, CJ Daniels, PP Dennis, AD Omer… - Proceedings of the …, 2000 - National Acad Sciences
We report the complete sequence of an extreme halophile, Halobacterium sp. NRC-1,
harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 …
harboring a dynamic 2,571,010-bp genome containing 91 insertion sequences representing 12 …
[HTML][HTML] Improved reference genome of Aedes aegypti informs arbovirus vector control
…, SN Mitchell, J Muehling, MR Murphy, AD Omer… - Nature, 2018 - nature.com
Female Aedes aegypti mosquitoes infect more than 400 million people each year with
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …
dangerous viral pathogens including dengue, yellow fever, Zika and chikungunya. Progress in …
3D genomics across the tree of life reveals condensin II as a determinant of architecture type
…, H Teunissen, BG St Hilaire, D Weisz, AD Omer… - Science, 2021 - science.org
We investigated genome folding across the eukaryotic tree of life. We find two types of three-dimensional
(3D) genome architectures at the chromosome scale. Each type appears and …
(3D) genome architectures at the chromosome scale. Each type appears and …
Homologs of small nucleolar RNAs in Archaea
In eukaryotes, dozens of posttranscriptional modifications are directed to specific nucleotides
in ribosomal RNAs (rRNAs) by small nucleolar RNAs (snoRNAs). We identified homologs …
in ribosomal RNAs (rRNAs) by small nucleolar RNAs (snoRNAs). We identified homologs …
The Juicebox Assembly Tools module facilitates de novo assembly of mammalian genomes with chromosome-length scaffolds for under $1000
…, D McAloose, C Pérez Estrada, BJ Novak, AD Omer… - BioRxiv, 2018 - biorxiv.org
… Novak, View ORCID ProfileArina D. Omer, View ORCID ProfileErez Lieberman Aiden …
Howard, Jean-Nicolas Audet, Lindsey Cantin, and Erich D. Jarvis. 2017. …
Howard, Jean-Nicolas Audet, Lindsey Cantin, and Erich D. Jarvis. 2017. …
[PDF][PDF] Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia
SARS-CoV-2 infects less than 1% of cells in the human body, yet it can cause severe
damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS-CoV-2 …
damage in a variety of organs. Thus, deciphering the non-cell-autonomous effects of SARS-CoV-2 …
In vitro reconstitution and activity of a C/D box methylation guide ribonucleoprotein complex
AD Omer, S Ziesche, H Ebhardt… - Proceedings of the …, 2002 - National Acad Sciences
The genomes of hyperthermophilic Archaea encode dozens of methylation guide, C/D box
small RNAs that guide 2′-O-methylation of ribose to specific sites in rRNA and various tRNAs…
small RNAs that guide 2′-O-methylation of ribose to specific sites in rRNA and various tRNAs…