Although elongation of telomeres is thought to be the prime function of reactivated telomerase
in cancers, this activity alone does not account for all of the properties that telomerase …

We describe a genome-wide gain-of-function screen for regulators of NF-κB, and identify
Rap1 (Trf2IP), as an essential modulator of NF-κB-mediated pathways. NF-κB is induced by …

The cornea is a specialized, transparent, avascular, immune-privileged, and heavily innervated
tissue that affords 2/3rd of refraction to the eye. Ocular injuries, infections, and genetic …

Although adeno-associated virus (AAV)-mediated gene therapy has been hindered by the
small viral packaging capacity of the vector, trans-splicing AAV vectors are able to package …

Purpose.: The present study was designed to understand the role of inflammatory cytokines
secreted by corneal epithelial cells in keratoconus (KC) and the response to treatment with …

The benefits of large-scale genetic studies for healthcare of the populations studied are well
documented, but these genetic studies have traditionally ignored people from some parts of …

Nanotechnology is touted as the next logical sequence in technological evolution. This has
led to a substantial surge in research activities pertaining to the development and …

The success of many gene therapy applications hinges on efficient whole body transduction.
In the case of muscular dystrophies, a therapeutic vector has to reach every muscle in the …

The trans-splicing (ts) and overlapping (ov) vectors expand the packaging capacity of adeno-associated
virus (AAV). But their application depends on the inherent properties of the …

In dry age-related macular degeneration (AMD), LCN2 (lipocalin 2) is upregulated. Whereas
LCN2 has been implicated in AMD pathogenesis, the mechanism remains unknown. Here, …