Antiangiogenic therapy leads to devascularization that limits tumor growth. However, the
benefits of angiogenesis inhibitors are typically transient and resistance often develops. In this …

Importance Per the World Health Organization 2016 integrative classification, newly
diagnosed glioblastomas are separated into isocitrate dehydrogenase gene 1 or 2 (IDH)–wild-type …

Gliomas comprise heterogeneous malignant glial and stromal cells. While blood vessel co-option
is a potential mechanism to escape anti-angiogenic therapy, the relevance of glial …

Glioblastoma is the most common malignant brain tumor, and it carries an extremely poor
prognosis. Attempts to develop targeted therapies have been hindered because the blood-…

Background Patients with incomplete surgical resection of medulloblastoma are controversially
regarded as having a marker of high-risk disease, which leads to patients undergoing …

Autophagy is a lysosomal degradation pathway that can sequester cytosolic material, including
organelles, nonspecifically in a process called nonselective macroautophagy, or target …

Purpose: To identify mediators of glioblastoma antiangiogenic therapy resistance and target
these mediators in xenografts. Experimental Design: We conducted microarray analysis …

Antiangiogenic therapies like bevacizumab offer promise for cancer treatment, but acquired
resistance, which often includes an aggressive mesenchymal phenotype, can limit the use of …

Postoperative cerebrospinal fluid (CSF) leak is a serious complication of transsphenoidal
surgery, which can lead to meningitis and often requires reparative surgery. We sought to …

Anti-angiogenic therapies for cancer such as VEGF neutralizing antibody bevacizumab
have limited durability. While mechanisms of resistance remain undefined, it is likely that …