Cell size is determined by the balance between protein synthesis and degradation. This
equilibrium is affected by hormones, nutrients, energy levels, mechanical stress and cytokines. …

Macrophages control the resolution of inflammation through the transition from a proinflammatory
(M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence for a role of …

Myotonic dystrophy is the most common muscular dystrophy in adults and the first recognized
example of an RNA-mediated disease. Congenital myotonic dystrophy (CDM1) and …

Mammalian target of rapamycin (mTOR) is a key regulator of cell growth that associates with
raptor and rictor to form the mTOR complex 1 (mTORC1) and mTORC2, respectively. Raptor …

Antisense oligonucleotides (AONs) hold promise for therapeutic correction of many genetic
diseases via exon skipping, and the first AON-based drugs have entered clinical trials for …

AMP‐activated protein kinase (AMPK) is a sensor of cellular energy status that plays a central
role in skeletal muscle metabolism. We used skeletal muscle‐specific AMPKα1α2 double‐…

Centronuclear myopathies (CNM) are congenital disorders associated with muscle weakness
and abnormally located nuclei in skeletal muscle. An autosomal dominant form of CNM …

We examined whether physical exercise affected the development of an autoimmune response,
experimental autoimmune encephalomyelitis (EAE), which is a demyelinating disease …

Autosomal dominant centronuclear myopathy (AD-CNM) is due to mutations in the gene
encoding dynamin 2 (DNM2) involved in endocytosis and intracellular membrane trafficking. To …

Myotonic dystrophy type 1 (DM1) is caused by an unstable CTG repeat expansion in the 3′UTR
of the DM protein kinase (DMPK) gene. DMPK transcripts carrying CUG expansions …