Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC),
and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases …

Ubiquitin-binding proteins play an important role in eukaryotes by translating differently
linked polyubiquitin chains into proper cellular responses. Current knowledge about ubiquitin-…

Many cellular proteins assemble into macromolecular protein complexes. The identification
of protein–protein interactions and quantification of their stoichiometry is therefore crucial to …

Epigenetic regulatory mechanisms and their enzymes are promising targets for malaria
therapeutic intervention; however, the epigenetic component of gene expression in P. falciparum …

Methylation of lysine 4 on histone H3 (H3K4) at promoters is tightly linked to transcriptional
regulation in human cells. At least six different COMPASS-like multisubunit (SET1/MLL) …

Gene knock outs (KOs) are efficiently engineered through CRISPR–Cas9-induced frameshift
mutations. While the efficiency of DNA editing is readily verified by DNA sequencing, a …

During the past decades, mass spectrometry (MS)-based proteomics has become an important
technology to identify protein–protein interactions (PPIs). The application of a quantitative …

The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through this …

Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein
substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin …

The vertebrate body plan and organs are shaped during a conserved embryonic phase
called the phylotypic stage. However, the mechanisms that guide the epigenome through this …