Type III secretion systems are toxin delivery systems that are present in a large number of
pathogens. A hallmark of all type III secretion systems studied to date is that expression of one …

Neutrophils are the first line of defense against bacterial infections, and the generation of
reactive oxygen species is a key part of their arsenal. Pathogens use detoxification systems to …

Pseudomonas aeruginosa uses a dedicated type III secretion system to deliver toxins directly
into the cytoplasm of host cells. While progress has been made in elucidating the function …

Pseudomonas aeruginosa is a leading cause of blinding corneal ulcers worldwide. To
determine the role of type III secretion in the pathogenesis of P. aeruginosa keratitis, corneas of …

The opportunistic pathogen Pseudomonas aeruginosa causes a variety of acute and chronic
infections. We identified a gene whose inactivation results in attenuation of virulence due to …

Type III secretion‐mediated cytotoxicity is one of the key virulence mechanisms of the
opportunistic pathogen Pseudomonas aeruginosa. Prior data from several laboratories have …

Biochemical studies have shown that the periplasmic protein disulfide oxidoreductase DsbC
can isomerize aberrant disulfide bonds. Here we present the first evidence for an in vivo …

▪ Abstract Disulfide bonds are required for the stability and function of a large number of
proteins. Genetic analysis in combination with biochemical studies have elucidated the main …

The Escherichia coli periplasmic protein DsbC is active both in vivo and in vitro as a protein
disulfide isomerase. For DsbC to attack incorrectly formed disulfide bonds in substrate …

A temperate, type IV pilus-dependent, double-stranded DNA bacteriophage named DMS3
was isolated from a clinical strain of Pseudomonas aeruginosa. A clear-plaque variant of this …