User profiles for Arnim Pause
 | Arnim Pause, M.Sc., Ph.D.Professor, Department of Biochemistry, Goodman Cencer Research Centre, McGill … Verified email at mcgill.ca Cited by 30540 |
[HTML][HTML] mTOR pathways in cancer and autophagy
TOR (target of rapamycin), an evolutionarily-conserved serine/threonine kinase, acts as a
central regulator of cell growth, proliferation and survival in response to nutritional status, …
central regulator of cell growth, proliferation and survival in response to nutritional status, …
[HTML][HTML] Hepatitis C therapeutics: current status and emerging strategies
Chronic infection with hepatitis C virus (HCV) is an emerging global epidemic. The development
of effective HCV antiviral therapeutics continues to be a daunting challenge owing to …
of effective HCV antiviral therapeutics continues to be a daunting challenge owing to …
The ever-evolving role of mTOR in translation
Control of translation allows for the production of stoichiometric levels of each protein in the
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
cell. Attaining such a level of fine-tuned regulation of protein production requires the …
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function
The cloning is described of two related human complementary DNAs encoding polypeptides
that interact specifically with the translation initiation factor elF-4E, which binds to the …
that interact specifically with the translation initiation factor elF-4E, which binds to the …
The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4γ and the translational repressors 4E-binding proteins
Eukaryotic translation initiation factor 4E (eIF-4E), which possesses cap-binding activity,
functions in the recruitment of mRNA to polysomes as part of a three-subunit complex, eIF-4F (…
functions in the recruitment of mRNA to polysomes as part of a three-subunit complex, eIF-4F (…
[PDF][PDF] mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation
mRNA translation is thought to be the most energy-consuming process in the cell. Translation
and energy metabolism are dysregulated in a variety of diseases including cancer, …
and energy metabolism are dysregulated in a variety of diseases including cancer, …
Inhibition of transcription elongation by the VHL tumor suppressor protein
Germline mutations in the von Hippel-Lindau tumor suppressor gene (VHL) predispose
individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central …
individuals to a variety of tumors, including renal carcinoma, hemangioblastoma of the central …
PHAS-I as a link between mitogen-activated protein kinase and translation initiation
PHAS-I is a heat-stable protein (relative molecular mass ≈ 12,400) found in many tissues. It
is rapidly phosphorylated in rat adipocytes incubated with insulin or growth factors. …
is rapidly phosphorylated in rat adipocytes incubated with insulin or growth factors. …
The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
A Pause, S Lee, RA Worrell… - Proceedings of the …, 1997 - National Acad Sciences
The inactivation of the von Hippel-Lindau (VHL) gene predisposes affected individuals to VHL
syndrome and is an early genetic event associated with sporadic renal cell carcinoma and …
syndrome and is an early genetic event associated with sporadic renal cell carcinoma and …
Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex
…, JW Conaway, RD Klausner, A Pause - Proceedings of the …, 1999 - National Acad Sciences
Mutations of von Hippel–Lindau disease (VHL) tumor-suppressor gene product (pVHL) are
found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic …
found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic …