Intracellular transport is interspersed with frequent reversals in direction due to the presence
of opposing kinesin and dynein motors on organelles that are carried as cargo. The cause …

Many cellular processes require large forces that are generated collectively by multiple
cytoskeletal motor proteins. Understanding how motors generate force as a team is therefore …

Liquid–liquid phase separation has been shown to underlie the formation and disassembly
of membraneless organelles in cells, but the cellular mechanisms that control this …

RNA concentration homeostasis involves coordinating RNA abundance and synthesis rates
with cell size. Here, we study this in human cells by combining genome-wide perturbations …

Diverse cellular processes are driven by the collective force from multiple motor proteins.
Disease-causing mutations cause aberrant function of motors, but the impact is observed at a …

The dual-specificity kinase DYRK3 controls the formation and dissolution of multiple biomolecular
condensates, regulating processes including stress recovery and mitotic progression. …

How the opposing activity of kinesin and dynein motors generates polarized distribution of
organelles inside cells is poorly understood and hotly debated [1, 2]. Possible explanations …

The dual-specificity kinase DYRK3 controls formation and dissolution of several intracellular
condensates thereby regulating various cell physiological processes. Here we report that …

Plasma membrane-associated platforms (PMAPs) form at specific sites of plasma membrane
by scaffolds including ERC1 and Liprin-α1. We identify a mechanism regulating PMAPs …

Transport of intracellular organelles along the microtubule cytoskeleton occurs in a bidirectional
manner due to opposing activity of microtubule-associated motor proteins of the kinesin …