Heterogeneity in strategies for survival and proliferation among the cells that constitute a
tumour is a driving force behind the evolution of resistance to cancer therapy. The rules …

Experiments show that evolutionary fitness landscapes can have a rich combinatorial
structure due to epistasis. For some landscapes, this structure can produce a computational …

Whether the nom de guerre is Mathematical Oncology, Computational or Systems Biology,
Theoretical Biology, Evolutionary Oncology, Bioinformatics, or simply Basic Science, there is …

* Abstract Recent agent-based computer simulations suggest that ethnocentrism, often
thought to rely on complex social cognition and learning, may have arisen through biological …

Evolutionary game theory mathematically conceptualizes and analyzes biological interactions
where one’s fitness not only depends on one’s own traits, but also on the traits of others. …

In this study, we experimentally measure the frequency-dependent interactions between a
gefitinib-resistant non–small cell lung cancer population and its sensitive ancestor via the …

Background: Tumours are diverse ecosystems with persistent heterogeneity in various
cancer hallmarks like self-sufficiency of growth factor production for angiogenesis and …

A typical study of space in evolutionary game theory starts with a specification of how local
interactions impact fitness, and then simulates that interaction over a model of space to show …

Cancer dynamics are an evolutionary game between cellular phenotypes. A typical
assumption in this modelling paradigm is that the probability of a given phenotypic strategy …

A compelling agent-based computer simulation suggests that ethnocentrism, often thought
to rely on complex social cognition and learning, may have arisen through biological …