Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of
kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological conditions…

Kynurenic acid (KYNA) is an endogenous tryptophan metabolite exerting neuroprotective and
anticonvulsant properties in the brain. However, its importance on the periphery is still not …

Covid-19 is the acute illness caused by SARS-CoV-2 with initial clinical symptoms such as
cough, fever, malaise, headache, and anosmia. After entry into cells, corona viruses (CoV) …

Previous studies have shown positive effects of long-term resveratrol (RSV) supplementation
in preventing pancreatic beta cell dysfunction, arterial stiffening and metabolic decline …

Notwithstanding the combination of cholinesterase (ChE) inhibition and calcium channel
blockade within a multitarget therapeutic approach is envisaged as potentially beneficial to …

A meta-analysis of publicly available transcriptomic datasets was performed to identify metabolic
pathways profoundly implicated in the progression and treatment of inflammatory bowel …

Cardiotoxicity remains the most common reason for failure during drug development.
Recently, the zebrafish (Danio rerio) model has emerged for the evaluation of drug-dependent …

Drug resistance has become a major concern in the field of infection management, therefore
searching for new antibacterial agents is getting more challenging. Our study presents an …

In this study, we present a complementary approach for obtaining an effective drug, based
on acriflavine (ACF) and zirconium-based metal–organic frameworks (MOFs), against SARS-…

In this work we describe the synthesis, Ca +2 channel blockade capacity and antioxidant
power of N 3 ,N 5 -bis(2-(5-methoxy-1H-indol-3-yl)ethyl)-2,6-dimethyl-4-aryl-1,4-dihydropyridine…