Background This study explores the magnetostatic properties of the Alzheimer's disease
brain using a recently proposed, magnetic resonance imaging, postprocessed contrast …

Pathological alterations to the locus coeruleus, the major source of noradrenaline in the
brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI …

Disruption of iron homeostasis as a consequence of aging is thought to cause iron levels to
increase, potentially promoting oxidative cellular damage. Therefore, understanding how this …

The hippocampus is proposed to be critical in distinguishing between similar experiences by
performing pattern separation computations that create orthogonalized representations for …

Although iron-mediated oxidative stress has been proposed as a potential pathomechanism
in Parkinson’s disease, the global distribution of iron accumulation in Parkinson’s disease …

Introduction Adults with Down syndrome (DS) invariably develop Alzheimer's disease (AD)
neuropathology. Understanding amyloid deposition in DS can yield crucial information about …

Individuals with Down syndrome (DS) are more likely to experience earlier onset of multiple
facets of physiological aging. This includes brain atrophy, beta amyloid deposition, cognitive …

The locus coeruleus (LC), a major origin of noradrenergic projections in the central nervous
system (CNS), may serve a critical role in the pathogenesis of neurodegenerative disorders …

The locus coeruleus (LC), the major origin of noradrenergic modulation of the central nervous
system, may play an important role in neuropsychiatric disorders including Parkinson's …

The locus coeruleus (LC) is the principal origin of noradrenaline in the brain. LC integrity
varies considerably across healthy older individuals, and is suggested to contribute to altered …