Enhanced Molecular Typing of Treponema pallidum: Geographical Distribution of Strain Types and Association with Neurosyphilis
…, MR Golden, A Centurion-Lara… - The Journal of …, 2010 - academic.oup.com
Background. Strain typing is a tool for determining the diversity and epidemiology of infections.
Methods. Treponema pallidum DNA was isolated from 158 patients with syphilis from the …
Methods. Treponema pallidum DNA was isolated from 158 patients with syphilis from the …
Identification of Treponema pallidum Subspecies pallidum in a 200-Year-Old Skeletal Specimen
CJ Kolman, A Centurion-Lara… - Journal of Infectious …, 1999 - academic.oup.com
Treponema pallidum subsp. pallidum, the causative agent of venereal syphilis, was detected
in a 200-year-old skeletal specimen from Easter Island. An initial diagnosis of treponemal …
in a 200-year-old skeletal specimen from Easter Island. An initial diagnosis of treponemal …
Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response
A Centurion-Lara, C Castro, L Barrett… - The Journal of …, 1999 - rupress.org
We have identified a family of genes that code for targets for opsonic antibody and protective
immunity in T. pallidum subspecies pallidum using two different approaches, subtraction …
immunity in T. pallidum subspecies pallidum using two different approaches, subtraction …
Origin of modern syphilis and emergence of a pandemic Treponema pallidum cluster
…, MR Fermepin, A Martinez, A Centurion Lara… - Nature …, 2016 - nature.com
The abrupt onslaught of the syphilis pandemic that started in the late fifteenth century
established this devastating infectious disease as one of the most feared in human history 1. …
established this devastating infectious disease as one of the most feared in human history 1. …
Gene conversion: a mechanism for generation of heterogeneity in the tprK gene of Treponema pallidum during infection
A Centurion‐Lara, RE LaFond, K Hevner… - Molecular …, 2004 - Wiley Online Library
The tprK gene sequence of Treponema pallidum subspecies pallidum (T. pallidum) is
heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is …
heterogeneous within and among isolates. Heterogeneity in the tprK open reading frame is …
Quantitation of rabbit cytokine mRNA by real-time RT-PCR
C Godornes, BT Leader, BJ Molini, A Centurion-Lara… - Cytokine, 2007 - Elsevier
Fundamental understanding of rabbit immunology and the use of the rabbit as a disease
model have long been hindered by the lack of immunological assays specific to this species. In …
model have long been hindered by the lack of immunological assays specific to this species. In …
Detection of Treponema pallidum by a sensitive reverse transcriptase PCR
A Centurion-Lara, C Castro, JM Shaffer… - Journal of Clinical …, 1997 - Am Soc Microbiol
Syphilis is diagnosed by serologic testing or by identification of the causative agent, Treponema
pallidum. The bacterium has historically been detected in clinical specimens by dark-…
pallidum. The bacterium has historically been detected in clinical specimens by dark-…
Antigenic variation in Treponema pallidum: TprK sequence diversity accumulates in response to immune pressure during experimental syphilis
…, BT Leader, LC Tantalo, A Centurion-Lara… - The Journal of …, 2010 - journals.aai.org
Pathogens that cause chronic infections often employ antigenic variation to evade the
immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative …
immune response and persist in the host. In Treponema pallidum (T. pallidum), the causative …
The flanking region sequences of the 15-kDa lipoprotein gene differentiate pathogenic treponemes
A Centurion-Lara, C Castro, R Castillo… - Journal of Infectious …, 1998 - academic.oup.com
The species Treponema pallidum includes three subspecies (pallidum, pertenue, and
endemicum) that cause syphilis, yaws, and bejel, respectively. A closely related species, …
endemicum) that cause syphilis, yaws, and bejel, respectively. A closely related species, …
[HTML][HTML] Fine Analysis of Genetic Diversity of the tpr Gene Family among Treponemal Species, Subspecies and Strains
A Centurion-Lara, L Giacani, C Godornes… - PLoS neglected …, 2013 - journals.plos.org
Background The pathogenic non-cultivable treponemes include three subspecies of
Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and the …
Treponema pallidum (pallidum, pertenue, endemicum), T. carateum, T. paraluiscuniculi, and the …