The evolutionarily conserved target of rapamycin (TOR) signaling controls growth, metabolism,
and aging. In the first robust demonstration of pharmacologically-induced life extension in …

EVIDENCE, an automated variant prioritization system, has been developed to facilitate whole
exome sequencing analyses. This study investigated the diagnostic yield of EVIDENCE in …

… to respond to an intermittent fasting diet - Arum - 2009 - Aging Cell - Wiley Online Library …
/Ola founders, provided by JJ Kopchick (Ohio University, Athens, OH), and outbred to Balb/c, …

Neurofibromatosis type 1 (NF1) is caused by heterozygous mutation in the NF1 gene. NF1
is one of the most common human genetic diseases. However, the overall genotype–…

Background Ambroxol (ABX) has been suggested as an augmentative pharmacological agent
for neuronopathic Gaucher disease (nGD). This study assessed the long-term safety and …

… JJK is supported in part by the state of Ohio's Eminent Scholars Program that includes a gift
from Milton and Lawrence Goll and by AG19899-05. The funders had no role in study design…

Background The diagnostic yield of whole-exome sequencing (WES) varies from 30%–50%
among patients with mild to severe neurodevelopmental delay (NDD)/intellectual disability (…

… For oxidative stress, the plates were put in a hyperbaric O 2 chamber at 40 psi O 2 for 48
hours at 20C, allowed to recover for 22 hours, and then scored for survival. For UV radiation …

… One major branch of this pathway extends through the Forkhead box class O 3A (FoxO3A)
transcription factor. In multiple studies of unrelated human populations, Foxo3a variants have …

Poor blood glucose homeostatic regulation is common, consequential, and costly for older
and elderly populations, resulting in pleiotrophically adverse clinical outcomes. …