Background Fibroblast growth factor 23 (FGF23) is a bone-derived phosphatonin that is
elevated in chronic kidney disease (CKD) and has been implicated in the development of …

Accelerated vascular aging is a condition that occurs as a complication of several highly
prevalent inflammatory conditions such as chronic kidney disease, cancer, HIV infection and …

Vascular progenitor cells show promise for the treatment of microvasculature endothelial
injury. We investigated the function of renal artery progenitor cells derived from radical …

Background Chronic kidney disease (CKD) patients have deficient levels of glutathione
peroxidase-3 (GPx3). We hypothesized that GPx3 deficiency may lead to cardiovascular disease …

Background Translation shutdown is a hallmark of late-phase, sepsis-induced kidney injury.
Methods for controlling protein synthesis in the kidney are limited. Reversing translation …

Background The myocardial cytoskeleton functions as the fundamental framework critical
for organelle function, bioenergetics and myocardial remodeling. To date, impairment of the …

Background: Myocardial fibrosis is a major life-limiting problem in chronic kidney disease (CKD).
Despite this, the molecular phenotype and metabolism of collagen fibrillogenesis in …

Background Endothelial cell injury is a common nidus of renal injury in patients and consistent
with the high prevalence of AKI reported during the coronavirus disease 2019 pandemic. …

The eIF2 initiation complex is central to maintaining a functional translation machinery.
Extreme stress such as life-threatening sepsis exposes vulnerabilities in this tightly regulated …

Introduction Vascular calcification is a significant contributor to accelerated cardiovascular
disease and mortality in patients with chronic kidney disease (CKD). We previously reported …