Oxygen-derived free radicals, collectively termed reactive oxygen species (ROS), play important
roles in immunity, cell growth, and cell signaling. In excess, however, ROS are lethal to …

Repair pathway "choice" at stalled mammalian replication forks is an important determinant
of genome stability; however, the underlying mechanisms are poorly understood. FANCM …

The major pathways of DNA double-strand break (DSB) repair are crucial for maintaining
genomic stability. However, if deployed in an inappropriate cellular context, these same repair …

Vertebrate replication forks arrested at interstrand DNA cross-links (ICLs) engage the Fanconi
anemia pathway to incise arrested forks, ‘unhooking’ the ICL and forming a double strand …

The nuclear factor (NF)-κB family of transcription factors are ubiquitous and pleiotropic
molecules that regulate the expression of more than 150 genes involved in a broad range of …

Small, approximately 10-kilobase microhomology-mediated tandem duplications are abundant
in the genomes of BRCA1-linked but not BRCA2-linked breast cancer. Here we define …

Replication fork stalling occurs when the replisome encounters a barrier to normal fork
progression. Replisome stalling events are common during scheduled DNA synthesis, but vary in …

Eukaryotic genomes are packaged in chromatin. The higher-order organization of nucleosome
core particles is controlled by the association of the intervening linker DNA with either the …

Classical non-homologous end joining (C-NHEJ) and homologous recombination (HR)
compete to repair mammalian chromosomal double strand breaks (DSBs). However, C-NHEJ …

Background Eukaryotic chromatin consists of nucleosome core particles connected by linker
DNA of variable length. Histone H1 associates with the linker DNA to stabilize the higher-…