Single-cell genomics is essential to chart tumor ecosystems. Although single-cell RNA-Seq (scRNA-Seq)
profiles RNA from cells dissociated from fresh tumors, single-nucleus RNA-Seq …

To explore the distinct genotypic and phenotypic states of melanoma tumors, we applied
single-cell RNA sequencing (RNA-seq) to 4645 single cells isolated from 19 patients, profiling …

Malignant abdominal fluid (ascites) frequently develops in women with advanced high-grade
serous ovarian cancer (HGSOC) and is associated with drug resistance and a poor …

Immune checkpoint inhibitors (ICIs) produce durable responses in some melanoma patients,
but many patients derive no clinical benefit, and the molecular underpinnings of such …

Immune responses to cancer are highly variable, with mismatch repair-deficient (MMRd)
tumors exhibiting more anti-tumor immunity than mismatch repair-proficient (MMRp) tumors. To …

Immune checkpoint blockade (ICB) results in durable disease control in a subset of patients
with advanced renal cell carcinoma (RCC), but mechanisms driving resistance are poorly …

Ex vivo systems that incorporate features of the tumor microenvironment and model the
dynamic response to immune checkpoint blockade (ICB) may facilitate efforts in precision …

Abstract Treatment of BRAF ‐mutant melanomas with MAP kinase pathway inhibitors is
paradigmatic of the promise of precision cancer therapy but also highlights problems with drug …

Resistance to immune checkpoint inhibitors (ICIs) is a key challenge in cancer therapy. To
elucidate underlying mechanisms, we developed Perturb-CITE-sequencing (Perturb-CITE-seq…

Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC),
but our understanding of their drivers, stability, and relationship to therapeutic …