Cancer immune evasion is a major stumbling block in designing effective anticancer
therapeutic strategies. Although considerable progress has been made in understanding how …

Trafficking of biological material across membranes is an evolutionary conserved mechanism
and is part of any normal cell homeostasis. Such transport is composed of active, passive, …

Activation of Notch-1 is known to be associated with the development and progression of
human malignancies including pancreatic cancer. Emerging evidence suggest that the …

Pancreatic cancer is a highly aggressive malignancy. This feature is believed to be partly
attributable to the chemotherapy-resistant characteristics of specific subgroups of pancreatic …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways, such …

Mutations in Kirsten rat sarcoma viral oncogene homolog (KRAS) are among the most
common aberrations in cancer, including non-small cell lung cancer (NSCLC). The lack of an …

Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most
of the anti-cancer therapies trigger apoptosis induction and related cell death networks to …

Proliferation is an important part of cancer development and progression. This is manifest
by altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Gastric cancer remains a major unmet clinical problem with over 1 million new cases worldwide.
It is the fourth most commonly occurring cancer in men and the seventh most commonly …

Deregulation of angiogenesis – the growth of new blood vessels from an existing vasculature
– is a main driving force in many severe human diseases including cancer. As such, tumor …