The KEAP1-NRF2 pathway is the key regulator of cellular defense against both extrinsic and
intrinsic oxidative and electrophilic stimuli. Since its discovery in the 1990s, its seminal role …

Accumulating evidence suggests that constitutively active Nrf2 has a pivotal role in cancer
as it induces pro-survival genes that promote cancer cell proliferation and chemoresistance. …

UDP-N-acetylglucosamine (UDP-GlcNAc) is a glucose metabolite with pivotal functions as a
key substrate for the synthesis of glycoconjugates like hyaluronan, and as a metabolic …

The NRF2 pathway is frequently activated in various cancer types, yet a comprehensive
analysis of its effects across different malignancies is currently lacking. We developed a NRF2 …

Hyaluronan content is a powerful prognostic factor in many cancer types, but the molecular
basis of its synthesis in cancer still remains unclear. Hyaluronan synthesis requires the …

The Kelch-like ECH-associated protein 1 (KEAP1) – Nuclear factor erythroid 2 -related
factor 2 (NRF2) pathway is the major transcriptional stress response system in cells against …

Genetic factors underlying coronary artery disease (CAD) have been widely studied using
genome-wide association studies (GWASs). However, the functional understanding of the …

Enzymatic and non-enzymatic oxidation of unsaturated fatty acids gives rise to reactive
species that covalently modify nucleophilic residues within redox sensitive protein sensors in a …

In vertebrates, hyaluronan is produced in the plasma membrane from cytosolic UDP-sugar
substrates by hyaluronan synthase 1–3 (HAS1–3) isoenzymes that transfer N-…

Hyaluronan synthases (HAS1–3) are unique in that they are active only when located in the
plasma membrane, where they extrude the growing hyaluronan (HA) directly into cell …