Genetic information is stored as chromatin, a well-organized assembly of DNA and proteins
that must be dynamically packed and unpacked to regulate gene expression. One way of …

Cas9 in complex with a programmable guide RNA targets specific double-stranded DNA for
cleavage. By harnessing Cas9 as a programmable loader of superhelicase to genomic DNA…

Transcriptionally repressive histone H3 lysine 27 methylation by Polycomb repressive complex
2 (PRC2) is essential for cellular differentiation and development. Here we report cryo–…

Highlights • We discuss current knowledge of immune evasion strategies used by γ-herpesviruses.
• Strategies are optimized to support acute, lytic and long-term, latent infection. • …

Modeling for safety risk often involves infrequent events with sparse data, and there is
simultaneously a low tolerance for both type 1 and type 2 errors. Frequent type 1 errors will cause …

Delivery of aerosols to the lung can treat various lung diseases. However, the conducting
airways are coated by a protective mucus layer with complex properties that make this form of …

… Xinyu (Ashlee) Feng and Dr. Matthew Poyton and I made JFX554 labeled nucleosomes with
… Feng and Dr. Anand Ranjan. JFX dyes were obtained as a gift from Luke Lavis at Janelia …

Enzyme immobilization in nano-space to maintain or even enhance their activity and stability
is generally challenging. In recent years, metal–organic frameworks (MOFs), covalent …

Background: Achilles tendinopathy is a frequent sports injury, and extracorporeal shock
wave therapy (ESWT) has been proposed as a treatment. Purpose: To compare outcomes …

The present studies examined the role and mechanism of action of infiltrating T lymphocytes
in the kidney during salt-sensitive hypertension. Infiltrating T lymphocytes in the Dahl salt-…