User profiles for Ashley Byrne
 | Ashley ByrneGenentech Verified email at gene.com Cited by 1904 |
[HTML][HTML] Tracheal aspirate RNA sequencing identifies distinct immunological features of COVID-19 ARDS
The immunological features that distinguish COVID-19-associated acute respiratory distress
syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report …
syndrome (ARDS) from other causes of ARDS are incompletely understood. Here, we report …
[HTML][HTML] Nanopore long-read RNAseq reveals widespread transcriptional variation among the surface receptors of individual B cells
Understanding gene regulation and function requires a genome-wide method capable of
capturing both gene expression levels and isoform diversity at the single-cell level. Short-read …
capturing both gene expression levels and isoform diversity at the single-cell level. Short-read …
Complete characterization of the human immune cell transcriptome using accurate full-length cDNA sequencing
The human immune system relies on highly complex and diverse transcripts and the proteins
they encode. These include transcripts encoding human leukocyte antigen (HLA) receptors …
they encode. These include transcripts encoding human leukocyte antigen (HLA) receptors …
[HTML][HTML] Depletion of Hemoglobin Transcripts and Long-Read Sequencing Improves the Transcriptome Annotation of the Polar Bear (Ursus maritimus)
Transcriptome studies evaluating whole blood and tissues are often confounded by
overrepresentation of highly abundant transcripts. These abundant transcripts are problematic, as …
overrepresentation of highly abundant transcripts. These abundant transcripts are problematic, as …
Realizing the potential of full-length transcriptome sequencing
Long-read sequencing holds great potential for transcriptome analysis because it offers
researchers an affordable method to annotate the transcriptomes of non-model organisms. This, …
researchers an affordable method to annotate the transcriptomes of non-model organisms. This, …
Linked genetic variation and not genome structure causes widespread differential expression associated with chromosomal inversions
Chromosomal inversions are widely thought to be favored by natural selection because
they suppress recombination between alleles that have higher fitness on the same genetic …
they suppress recombination between alleles that have higher fitness on the same genetic …
The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans
Molecular characterization of cell types using single-cell transcriptome sequencing is
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …
revolutionizing cell biology and enabling new insights into the physiology of human organs. We …
[HTML][HTML] COVID-19 ARDS is characterized by a dysregulated host response that differs from cytokine storm and is modified by dexamethasone
We performed comparative lower respiratory tract transcriptional profiling of 52 critically ill
patients with the acute respiratory distress syndrome (ARDS) from COVID-19 or from other …
patients with the acute respiratory distress syndrome (ARDS) from COVID-19 or from other …
Type I interferon autoantibodies are associated with systemic immune alterations in patients with COVID-19
…, T Le Voyer, A Whatley, Y Si, A Byrne… - Science translational …, 2021 - science.org
Neutralizing autoantibodies against type I interferons (IFNs) have been found in some patients
with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute …
with critical coronavirus disease 2019 (COVID-19), the disease caused by severe acute …
Reintroduction of the archaic variant of NOVA1 in cortical organoids alters neurodevelopment
INTRODUCTION Current views of human evolution, as supported by the fossil record,
indicate that many hominin lineage branches arose, but only one survived to the present. …
indicate that many hominin lineage branches arose, but only one survived to the present. …