Inhibition of the metabolic regulator AMP-activated protein kinase (AMPK) is increasingly
being investigated for its therapeutic potential in diseases where AMPK hyperactivity results in …

SBI-0206965, originally identified as an inhibitor of the autophagy initiator kinase ULK1, has
recently been reported as a more potent and selective AMP-activated protein kinase (AMPK…

The AMP-activated protein kinase (AMPK) αβγ heterotrimer regulates cellular energy
homeostasis with tissue-specific isoform distribution. Small-molecule activation of skeletal muscle …

Physical exercise elicits physiological metabolic perturbations such as energetic and
oxidative stress; however, a diverse range of cellular processes are stimulated in response to …

The AMP-activated protein kinase (AMPK) αβγ heterotrimer is a primary cellular energy sensor
and central regulator of energy homeostasis. Activating skeletal muscle AMPK with small …

Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of
function of the mitochondrial tricarboxylic acid (TCA) cycle enzyme subunit succinate …

Objective The metabolic master-switch AMP-activated protein kinase (AMPK) mediates
insulin-independent glucose uptake in muscle and regulates the metabolic activity of brown and …

AMP-activated kinase (AMPK) and target of rapamycin (TOR) signalling coordinate cell growth,
proliferation, metabolism and cell survival with the nutrient environment of cells. The poor …

AMP-activated protein kinase (AMPK) is a master regulator of cellular energy homeostasis
and a therapeutic target for metabolic diseases. Co/post-translational N-myristoylation of …

… All in vitro testing was carried out in a temperaturecontrolled, Elconap laboratory oven;
the oven was maintained at 37 C and the temperature was checked daily. A Chatillon spring-…