Human longevity is heritable, but genome-wide association (GWA) studies have had limited
success. Here, we perform two meta-analyses of GWA studies of a rigorous longevity …

Predicting longer-term mortality risk requires collection of clinical data, which is often
cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic …

Sleep is an essential human function but its regulation is poorly understood. Using accelerometer
data from 85,670 UK Biobank participants, we perform a genome-wide association …

Progressive loss of renal function is associated with a dysregulation of circulating T cells
that may underlie their impaired T-cell immunity. Here we tested whether end-stage renal …

Homozygosity has long been associated with rare, often devastating, Mendelian disorders 1,
and Darwin was one of the first to recognize that inbreeding reduces evolutionary fitness 2. …

Genomic analysis of longevity offers the potential to illuminate the biology of human aging.
Here, using genome-wide association meta-analysis of 606,059 parents’ survival, we …

Leukocyte telomere length (LTL) is a heritable biomarker of genomic aging. In this study, we
perform a genome-wide meta-analysis of LTL by pooling densely genotyped and imputed …

Background End-stage renal disease (ESRD) patients treated with renal replacement
therapy (RRT) have premature immunologically aged T cells which may underlie uremia-…

Background The growing field of metabolomics has opened up new opportunities for prediction
of type 2 diabetes (T2D) going beyond the classical biochemistry assays. Objectives We …

In many species, the offspring of related parents suffer reduced reproductive success, a
phenomenon known as inbreeding depression. In humans, the importance of this effect has …