User profiles for Ashwani K. Thakur
 | Ashwani Kumar ThakurBiological Sciences and Bioengineering Department, Indian Institute of Technology, Kanpur … Verified email at iitk.ac.in Cited by 3005 |
Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism
AK Thakur, M Jayaraman, R Mishra, M Thakur… - Nature structural & …, 2009 - nature.com
Simple polyglutamine (polyQ) peptides aggregate in vitro via a nucleated growth pathway
directly yielding amyloid-like aggregates. We show here that the 17-amino-acid flanking …
directly yielding amyloid-like aggregates. We show here that the 17-amino-acid flanking …
[HTML][HTML] The toxicological mechanisms of environmental soot (black carbon) and carbon black: focus on oxidative stress and inflammatory pathways
R Niranjan, AK Thakur - Frontiers in immunology, 2017 - frontiersin.org
The environmental soot and carbon blacks (CBs) cause many diseases in humans, but their
underlying mechanisms of toxicity are still poorly understood. Both are formed after the …
underlying mechanisms of toxicity are still poorly understood. Both are formed after the …
Oligoproline effects on polyglutamine conformation and aggregation
A Bhattacharyya, AK Thakur, VM Chellgren… - Journal of molecular …, 2006 - Elsevier
There are nine known expanded CAG repeat neurological diseases, including Huntington's
disease (HD), each involving the repeat expansion of polyglutamine (polyGln) in a different …
disease (HD), each involving the repeat expansion of polyglutamine (polyGln) in a different …
Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments
The 17-amino-acid N-terminal segment (htt NT ) that leads into the polyglutamine (polyQ)
segment in the Huntington's disease protein huntingtin (htt) dramatically increases aggregation …
segment in the Huntington's disease protein huntingtin (htt) dramatically increases aggregation …
[HTML][HTML] Therapeutic implication of L-phenylalanine aggregation mechanism and its modulation by D-phenylalanine in phenylketonuria
Self-assembly of phenylalanine is linked to amyloid formation toxicity in phenylketonuria
disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying …
disease. We are demonstrating that L-phenylalanine self-assembles to amyloid fibrils at varying …
Mutational analysis of the structural organization of polyglutamine aggregates
The formation of amyloid-like aggregates by expanded polyglutamine (polyGln) sequences
is suspected to play a critical role in the neuropathology of Huntington's disease and other …
is suspected to play a critical role in the neuropathology of Huntington's disease and other …
Polyglutamine aggregation nucleation: thermodynamics of a highly unfavorable protein folding reaction
AM Bhattacharyya, AK Thakur… - Proceedings of the …, 2005 - National Acad Sciences
Polyglutamine (polyGln) aggregation is implicated in the disease progression of Huntington's
disease and other expanded CAG repeat diseases. PolyGln aggregation in vitro follows a …
disease and other expanded CAG repeat diseases. PolyGln aggregation in vitro follows a …
Understanding the self-assembly of Fmoc–phenylalanine to hydrogel formation
Hydrogels of low molecular weight molecules are important in biomedical applications.
Multiple factors are responsible for hydrogel formation, but their role in governing self-assembly …
Multiple factors are responsible for hydrogel formation, but their role in governing self-assembly …
Kinetics and thermodynamics of amyloid assembly using a high‐performance liquid chromatography–based sedimentation assay
B O'Nuallain, AK Thakur, AD Williams… - Methods in …, 2006 - Elsevier
Nonnative protein aggregation has been classically treated as an amorphous process occurring
by colloidal coagulation kinetics and proceeding to an essentially irreversible endpoint …
by colloidal coagulation kinetics and proceeding to an essentially irreversible endpoint …
Effect of 12 mg vs 6 mg of dexamethasone on the number of days alive without life support in adults with COVID-19 and severe hypoxemia: the COVID STEROID 2 …
…, S Shirsekar, S Kansal, R Dahiya, VK Thakur… - Jama, 2021 - jamanetwork.com
Importance A daily dose with 6 mg of dexamethasone is recommended for up to 10 days in
patients with severe and critical COVID-19, but a higher dose may benefit those with more …
patients with severe and critical COVID-19, but a higher dose may benefit those with more …