Glioblastomas are aggressive primary brain cancers that recur as therapy-resistant tumors.
Myeloid cells control glioblastoma malignancy, but their dynamics during disease …

… Author links open overlay panel Chris Fotis 1 , Asier Antoranz 1 2 , Dimitris Hatziavramidis
1 , Theodore Sakellaropoulos 1 , Leonidas G. Alexopoulos 1 2 … Antoranz, et al. …

Single-cell omics aim at charting the different types and properties of all cells in the human
body in health and disease. Over the past years, myriads of cellular phenotypes have been …

The stromal compartment of the tumor microenvironment consists of a heterogeneous set of
tissue-resident and tumor-infiltrating cells, which are profoundly moulded by cancer cells. An …

Most clinically applied cancer immunotherapies rely on the ability of CD8 + cytolytic T cells
to directly recognize and kill tumour cells 1 , 2 – 3 . These strategies are limited by the …

Epidemiological and clinical reports indicate that SARS-CoV-2 virulence hinges upon the
triggering of an aberrant host immune response, more so than on direct virus-induced cellular …

The state-of-the-art for melanoma treatment has recently witnessed an enormous revolution,
evolving from a chemotherapeutic, “one-drug-for-all” approach, to a tailored molecular- and …

Rejection remains the main cause of premature graft loss after kidney transplantation, despite
the use of potent immunosuppression. This highlights the need to better understand the …

To better understand intrinsic resistance to immune checkpoint blockade (ICB), we established
a comprehensive view of the cellular architecture of the treatment-naive melanoma …

Aims As important prognostic and predictive information can be obtained from the composition,
functionality and spatial arrangement of different immune cell subtypes, this study aims at …