Heterozygous variants in GBA1, encoding glucocerebrosidase (GCase), are the most
common genetic risk factor for Parkinson's disease (PD). Moreover, sporadic PD patients also …

Background: Prior research conducted in model rats of CAA Type 1 (rTg-DI) identified a range
of cerebrospinal fluid biomarker candidates associated with sCAA pathology. This list of …

The additive effect of genetic risk variants on disease risk is a popular but typically unproven
hypothesis. We investigated this hypothesis mechanistically for Parkinson’s disease risk …

Background The additive mechanistic effect of genetic risk variants for Parkinson’s disease (PD)
is a plausible but largely unproven hypothesis. We investigated the mechanistic …

Biallelic glucocerebrosidase (GBA) mutations cause the lysosomal storage disorder Gaucher
disease (GD), while heterozygous GBA variants are the strongest and most common …

Purpose Although there have been many population-based studies of age-related macular
degeneration (AMD), only limited information is available in Asia on the epidemiology of …

This paper examines how the negotiation of the traumas of slavery and its legacies in Yaa
Gyasi’s Homegoing (2016) deviates from traditional trauma literature in terms of its form and …

… We thank Nadine van Donk and Evert de Jonge for direct and excellent processing of dd-cfDNA,
and Marjolein Dieterich and Rens Kraaijeveld for help with the flow cytometry …

Approximately 25% of the patients with muscle-invasive bladder cancer (MIBC) who are
clinically node negative have occult lymph node metastases at radical cystectomy (RC) and …

… The authors would like to thank Frans van den Brandt, Saskia van der Velde-Visser, and
Marlie HM Jacobs-Camps for their work in culturing the fibroblasts and Astrid van Rens for …