[HTML][HTML] A cAMP-related gene network in microglia is inversely regulated by morphine tolerance and withdrawal

KR Coffey, AJ Lesiak, RE Marx, EK Vo… - … psychiatry global open …, 2022 - Elsevier
Background Microglia have recently been implicated in opioid dependence and withdrawal.
Mu opioid receptors are expressed in microglia, and microglia form intimate connections …

Sequencing the serotonergic neuron translatome reveals a new role for Fkbp5 in stress

AJ Lesiak, K Coffey, JH Cohen, KJ Liang… - Molecular …, 2021 - nature.com
Serotonin is a key mediator of stress, anxiety, and depression, and novel therapeutic targets
within serotonin neurons are needed to combat these disorders. To determine how stress …

Restoration of physiological expression of 5-HT6 receptor into the primary cilia of null mutant neurons lengthens both primary cilia and dendrites

AJ Lesiak, M Brodsky, N Cohenca, AG Croicu… - Molecular …, 2018 - ASPET
5-HT 6 (serotonin) receptors are promising targets for a variety of neuropsychiatric disorders
and have been linked to several cellular signaling cascades. Endogenous 5-HT 6 receptors …

[HTML][HTML] Stress induces divergent gene expression among lateral habenula efferent pathways

MR Levinstein, KR Coffey, RG Marx, AJ Lesiak… - Neurobiology of …, 2020 - Elsevier
Running Title: LHb efferent pathways diverge after stressAbstract word count:
192Introduction word count including citations: 719Discussion word count including citations: …

5-HT1B Receptor-Mediated Activation of ERK1/2 Requires Both Gαi/o and β-Arrestin Proteins

…, AW Gibson, MR Levinstein, AJ Lesiak… - ACS chemical …, 2019 - ACS Publications
5-HT 1B receptors modulate synaptic serotonin (5-HT) levels and play a significant role in
the regulation of emotional behaviors. These receptors are Gα i/o -coupled and inhibit …

[HTML][HTML] Turning towards greater equity and access with online teacher professional development

AJ Lesiak, JC Griswold, H Starks - Journal of STEM outreach, 2021 - ncbi.nlm.nih.gov
Access to professional development opportunities promotes equity for both teachers and
students. We identified time, distance, and childcare needs as limiting factors for teachers …

Ribotag-seq reveals a compensatory camp responsive gene network in striatal microglia induced by morphine withdrawal

KR Coffey, AJ Lesiak, RG Marx, EK Vo, GA Garden… - bioRxiv, 2020 - biorxiv.org
Microglia have recently been implicated in dependence to opioids. To investigate this
directly, we used RNA sequencing of ribosome associated RNAs from striatal microglia (RiboTag-…

[PDF][PDF] A Creative Communication Partnership to Promote Curricula Dissemination on Social Media

AJ Lesiak, N Malik, JC Griswold - Journal of STEM Outreach, 2024 - jstemoutreach.org
Genome Sciences Education Outreach (GSEO) has developed innovative programs that
bring leading-edge science to teachers and students in K-12 schools. Disseminating …

RiboTag-Seq Reveals the Activation of the Unfolded Protein Response in Striatal Microglia Induced by Ethanol Withdrawal

BD Dufour, KR Coffey, AJ Lesiak, GA Garden… - bioRxiv, 2020 - biorxiv.org
Repeated cycles of alcohol intoxication and withdrawal both induce profound changes in
gene expression that can contribute to the physiological and behavioral consequences of …

Blood Sugar Balance: A Glucose Metabolism Web Game for Diabetes Education

AJ Lesiak, JC Griswold - The American biology teacher, 2023 - online.ucpress.edu
Blood Sugar Balance (BSB) is an accessible web-based game, created as an extension of
our federally funded type 2 diabetes curriculum for high school biology classrooms. Modeling …