Rab35 GTPase recruits NDP52 to autophagy targets

A MinowaNozawa, T Nozawa… - The EMBO …, 2017 - embopress.org
Autophagy targets intracellular molecules, damaged organelles, and invading pathogens
for degradation in lysosomes. Recent studies have identified autophagy receptors that …

[HTML][HTML] TBC1D9 regulates TBK1 activation through Ca2+ signaling in selective autophagy

T Nozawa, S Sano, A Minowa-Nozawa, H Toh… - Nature …, 2020 - nature.com
Invading microbial pathogens can be eliminated selectively by xenophagy. Ubiquitin-mediated
autophagy receptors are phosphorylated by TANK-binding kinase 1 (TBK1) and recruited …

[HTML][HTML] Rab41-mediated ESCRT machinery repairs membrane rupture by a bacterial toxin in xenophagy

…, H Toh, J Iibushi, K Kogai, A Minowa-Nozawa… - Nature …, 2023 - nature.com
Xenophagy, a type of selective autophagy, is a bactericidal membrane trafficking that targets
cytosolic bacterial pathogens, but the membrane homeostatic system to cope with bacterial …

The STX6-VTI1B-VAMP3 complex facilitates xenophagy by regulating the fusion between recycling endosomes and autophagosomes

T Nozawa, A Minowa-Nozawa, C Aikawa, I Nakagawa - Autophagy, 2017 - Taylor & Francis
Macroautophagy/autophagy plays a critical role in immunity by directly degrading invading
pathogens such as Group A Streptococcus (GAS), through a process that has been named …

[HTML][HTML] Autophagy Receptor Tollip Facilitates Bacterial Autophagy by Recruiting Galectin-7 in Response to Group A Streptococcus Infection

CY Lin, T Nozawa, A Minowa-Nozawa… - Frontiers in Cellular …, 2020 - frontiersin.org
Bacterial autophagy—a type of macroautophagy that is also termed xenophagy—selectively
targets intracellular bacteria such as group A Streptococcus (GAS), a ubiquitous pathogen …

LAMTOR2/LAMTOR1 complex is required for TAX1BP1‐mediated xenophagy

CY Lin, T Nozawa, A MinowaNozawa… - Cellular …, 2019 - Wiley Online Library
Xenophagy, also known as antibacterial autophagy, plays a role in host defence against
invading pathogens such as Group A Streptococcus (GAS) and Salmonella. In xenophagy, …

Rab17‐mediated recycling endosomes contribute to autophagosome formation in response to Group A Streptococcus invasion

B Haobam, T Nozawa, A MinowaNozawa… - Cellular …, 2014 - Wiley Online Library
Autophagy plays a crucial role in host defence by facilitating the degradation of invading
bacteria such as G roup A S treptococcus ( GAS ). GAS ‐containing autophagosome‐like …

[HTML][HTML] NLRX1 Negatively Regulates Group A Streptococcus Invasion and Autophagy Induction by Interacting With the Beclin 1–UVRAG Complex

…, M Karimine, T Nozawa, A Minowa-Nozawa… - Frontiers in cellular …, 2018 - frontiersin.org
Group A Streptococcus (GAS) can invade epithelial cells; however, these bacteria are targeted
and eventually destroyed by autophagy. Members of the Nod-like receptor (NLR) family …

Intracellular Group A Streptococcus Induces Golgi Fragmentation To Impair Host Defenses through Streptolysin O and NAD-Glycohydrolase

T Nozawa, J Iibushi, H Toh, A Minowa-Nozawa… - MBio, 2021 - Am Soc Microbiol
Group A Streptococcus (GAS; Streptococcus pyogenes ) is a major human pathogen that
causes streptococcal pharyngitis, skin and soft tissue infections, and life-threatening conditions …

Group A Streptococcus modulates RAB1- and PIK3C3 complex-dependent autophagy

H Toh, T Nozawa, A Minowa-Nozawa, M Hikichi… - Autophagy, 2020 - Taylor & Francis
Autophagy selectively targets invading bacteria to defend cells, whereas bacterial pathogens
counteract autophagy to survive in cells. The initiation of canonical autophagy involves the …