The basement membrane (BM) is a thin layer of extracellular matrix (ECM) beneath nearly
all epithelial cell types that is critical for cellular and tissue function. It is composed of …

Drosophila melanogaster plasmatocytes, the phagocytic cells among hemocytes, are essential
for immune responses, but also play key roles from early development to death through …

Cells migrate through crowded microenvironments within tissues during normal development,
immune response, and cancer metastasis. Although migration through pores and tracks in …

The infiltration of immune cells into tissues underlies the establishment of tissue-resident
macrophages and responses to infections and tumors. Yet the mechanisms immune cells …

Cellular metabolism must adapt to changing demands to enable homeostasis. During immune
responses or cancer metastasis, cells leading migration into challenging environments …

Migrating cells penetrate tissue barriers during development, inflammatory responses, and
tumor metastasis. We study if migration in vivo in such three-dimensionally confined …

10.7554/eLife.41801.001 Aberrant display of the truncated core1 O-glycan T-antigen is a
common feature of human cancer cells that correlates with metastasis. Here we show that T-…

Unpaired ligands are secreted signals that act via a GP130-like receptor, domeless, to activate
JAK/STAT signalling in Drosophila. Like many mammalian cytokines, unpaireds can be …

Optogenetics has been harnessed to shed new mechanistic light on current and future
therapeutic strategies. This has been to date achieved by the regulation of ion flow and electrical …

Public administration reform at all governmental levels constitutes an important component
of the transformation process from a centralized system to democratic governance. This …