SARS-CoV-2 spike protein co-opts VEGF-A/neuropilin-1 recepto... : PAIN SARS-CoV-2 spike
protein co-opts VEGF-A/neuropilin-1 receptor signaling to induce analgesia : PAIN …

Voltage-gated sodium channels are crucial determinants of neuronal excitability and signaling.
Trafficking of the voltage-gated sodium channel NaV1.7 is dysregulated in neuropathic …

Treatments for chronic pain are inadequate, and new options are needed. Nonpharmaceutical
approaches are especially attractive with many potential advantages including safety. …

Migraine headache results from activation of meningeal nociceptors, however, the
hypothalamus is activated many hours before the emergence of pain. How hypothalamic neural …

T-type calcium channels regulate neuronal excitability and are important contributors of
pain processing. CaV3.2 channels are the major isoform expressed in nonpeptidergic and …

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disease linked to mutations of
the Nf1 gene. Patients with NF1 commonly experience severe pain. Studies on mice with …

Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and regulating …

Targeting proteins within the N-type voltage-gated calcium channel (CaV2. 2) complex has
proven to be an effective strategy for developing novel pain therapeutics. We describe a …

Neuropilin-1 (NRP-1) is a multifunctional transmembrane receptor for ligands that affect
developmental axonal growth and angiogenesis. In addition to a role in cancer, NRP-1 is a …

Pain is more prevalent in women for reasons that remain unclear. We have identified a
mechanism of injury-free nociceptor sensitization and opioid-induced hyperalgesia (OIH) …