ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions
…, JL Moake, L Nolasco, A Bernardo… - Blood, The Journal …, 2002 - ashpublications.org
Thrombotic thrombocytopenic purpura (TTP) is a devastating thrombotic disorder caused by
widespread microvascular thrombi composed of platelets and von Willebrand factor (VWF). …
widespread microvascular thrombi composed of platelets and von Willebrand factor (VWF). …
Effects of inflammatory cytokines on the release and cleavage of the endothelial cell–derived ultralarge von Willebrand factor multimers under flow
A Bernardo, C Ball, L Nolasco, JF Moake, J Dong - Blood, 2004 - ashpublications.org
ADAMTS13 cleaves ultralarge and hyperreactive von Willebrand factor (ULVWF) freshly
released from activated endothelial cells to smaller and less active forms. This process may be …
released from activated endothelial cells to smaller and less active forms. This process may be …
Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus
Q Xu, A Bernardo, D Walker, T Kanegawa… - Journal of …, 2006 - Soc Neuroscience
To study the profile and regulation of apolipoprotein E (apoE) expression in the CNS, we
generated mice in which apoE expression can be detected in vivo with unprecedented …
generated mice in which apoE expression can be detected in vivo with unprecedented …
Apolipoprotein E4 causes age-and Tau-dependent impairment of GABAergic interneurons, leading to learning and memory deficits in mice
…, N Bien-Ly, Q Xu, G Li, A Bernardo… - Journal of …, 2010 - Soc Neuroscience
Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease. However,
the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice …
the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice …
[PDF][PDF] GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice
G Li, N Bien-Ly, Y Andrews-Zwilling, Q Xu, A Bernardo… - Cell stem cell, 2009 - cell.com
Apolipoprotein (apo) E, a polymorphic protein with three isoforms (apoE2, apoE3, and
apoE4), is essential for lipid homeostasis. Carriers of apoE4 are at higher risk for developing …
apoE4), is essential for lipid homeostasis. Carriers of apoE4 are at higher risk for developing …
P-selectin anchors newly released ultralarge von Willebrand factor multimers to the endothelial cell surface
A Padilla, JL Moake, A Bernardo, C Ball, Y Wang… - Blood, 2004 - ashpublications.org
von Willebrand factor (VWF) released from endothelium is ultralarge (UL) and hyperreactive.
If released directly into plasma, it can spontaneously aggregate platelets, resulting in …
If released directly into plasma, it can spontaneously aggregate platelets, resulting in …
[HTML][HTML] ADAMTS-13 metalloprotease interacts with the endothelial cell-derived ultra-large von Willebrand factor
J Dong, JL Moake, A Bernardo, K Fujikawa… - Journal of Biological …, 2003 - ASBMB
Thrombotic thrombocytopenic purpura is caused by congenital or acquired deficiency of
ADAMTS-13, a metalloprotease that cleaves the endothelium-derived ultra-large multimers of …
ADAMTS-13, a metalloprotease that cleaves the endothelium-derived ultra-large multimers of …
Hemolytic uremic syndrome–associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor …
LH Nolasco, NA Turner, A Bernardo, Z Tao, TG Cleary… - Blood, 2005 - ashpublications.org
Shiga toxin 1 (Stx-1) and Stx-2 produced by enterohemorrhagic Escherichia coli cause the
diarrhea-associated hemolytic uremic syndrome (HUS). This type of HUS is characterized by …
diarrhea-associated hemolytic uremic syndrome (HUS). This type of HUS is characterized by …
Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the CNS
Q Xu, D Walker, A Bernardo, J Brodbeck… - Journal of …, 2008 - Soc Neuroscience
Neuronal expression of apolipoprotein (apo) E4 may contribute to the pathogenesis of
Alzheimer's disease (AD). In studying how apoE expression is regulated in neurons, we identified …
Alzheimer's disease (AD). In studying how apoE expression is regulated in neurons, we identified …
[HTML][HTML] Cellular source of apolipoprotein E4 determines neuronal susceptibility to excitotoxic injury in transgenic mice
…, GQ Yu, JJ Palop, S Chang, A Bernardo… - The American journal of …, 2010 - Elsevier
The lipid transport protein apolipoprotein E (apoE) is abundantly expressed in the brain. Its
main isoforms in humans are apoE2, apoE3, and apoE4. ApoE4 is the major known genetic …
main isoforms in humans are apoE2, apoE3, and apoE4. ApoE4 is the major known genetic …