Diffusion in the plasma membrane of living cells is often found to display anomalous dynamics.
However, the mechanism underlying this diffusion pattern remains highly controversial. …

Cells contain hundreds of organelles and macromolecular assemblies. Obtaining a
complete understanding of their intricate organization requires the nanometre-level, three-…

Metabolic coordination between neurons and astrocytes is critical for the health of the brain.
However, neuron-astrocyte coupling of lipid metabolism, particularly in response to neural …

INTRODUCTION The endoplasmic reticulum (ER) is a continuous, membrane-bound
organelle, spanning from the nuclear envelope to the outer cell periphery, that contacts and …

Cellular versatility depends on accurate trafficking of diverse proteins to their organellar
destinations. For the secretory pathway (followed by approximately 30% of all proteins), the …

Rhodamine dyes exist in equilibrium between a fluorescent zwitterion and a nonfluorescent
lactone. Tuning this equilibrium toward the nonfluorescent lactone form can improve cell-…

Understanding cellular architecture is essential for understanding biology. Electron
microscopy (EM) uniquely visualizes cellular structures with nanometre resolution. However, …

Lipid droplets (LDs) are neutral lipid storage organelles that transfer lipids to various organelles
including peroxisomes. Here, we show that the hereditary spastic paraplegia protein M1 …

The endoplasmic reticulum (ER) forms a dynamic network that contacts other cellular
membranes to regulate stress responses, calcium signalling and lipid transfer. Here, using high-…

Voltage-gated K + (Kv) channels regulate membrane potential in many cell types. Although
the channel surface density and location must be well controlled, little is known about Kv …