Metabolic networks are interconnected and influence diverse cellular processes. The protein-metabolite
interactions that mediate these networks are frequently low affinity and …

Our ability to rationally optimize allosteric regulation is limited by incomplete knowledge of the
mutations that tune allostery. Are these mutations few or abundant, structurally localized or …

The proper balance of synthesis, folding, modification, and degradation of proteins, also
known as protein homeostasis, is vital to cellular health and function. The unfolded protein …

Metabolism is highly interconnected and also has profound effects on other cellular
processes. However, the interactions between metabolites and proteins that mediate this …

Public discourse has historically been a dynamic arena of social change. It has the power to
define social norms as well as modify nationwide consensus. If enough audience members …

During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane
and secretory protein folding that is vital for proper cellular function. The ER-resident HSP70 …

FicD is an Endoplasmic Reticulum (ER) transmembrane protein that reversibly AMPylates
and deAMPylates BiP, an HSP70 chaperone and master regulator of the Unfolded Protein …

During homeostasis, the endoplasmic reticulum (ER) maintains productive transmembrane
and secretory protein folding that is vital for proper cellular function. The ER-resident …

The discovery of the mitochondrial pyruvate carrier (MPC) and the ability to alter the cellular
partitioning of pyruvate has allowed for exploration into the consequences for a cell with …

The folate and methionine cycles, constituting one-carbon metabolism, are critical pathways
for cell survival. Intersecting these two cycles, 5,10-methylenetetrahydrofolate reductase (…