[HTML][HTML] Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy

T Larcher, A Lafoux, L Tesson, S Remy, V Thepenier… - PloS one, 2014 - journals.plos.org
A few animal models of Duchenne muscular dystrophy (DMD) are available, large ones such
as pigs or dogs being expensive and difficult to handle. Mdx (X-linked muscular dystrophy) …

[HTML][HTML] In vivo spatiotemporal control of voltage-gated ion channels by using photoactivatable peptidic toxins

…, L Lopez, L Filipis, H Meudal, A Lafoux… - Nature …, 2022 - nature.com
Photoactivatable drugs targeting ligand-gated ion channels open up new opportunities for
light-guided therapeutic interventions. Photoactivable toxins targeting ion channels have the …

Evaluation of the dystrophin carboxy-terminal domain for micro-dystrophin gene therapy in cardiac and skeletal muscles in the DMDmdx rat model

A Bourdon, V François, L Zhang, A Lafoux, B Fraysse… - Gene Therapy, 2022 - nature.com
Duchenne muscular dystrophy (DMD) is a muscle wasting disorder caused by mutations in
the gene encoding dystrophin. Gene therapy using micro-dystrophin (MD) transgenes and …

[HTML][HTML] Characterization of brain dystrophins absence and impact in dystrophin-deficient Dmdmdx rat model

D Caudal, V François, A Lafoux, M Ledevin, I Anegon… - PLoS …, 2020 - journals.plos.org
Duchenne Muscular Dystrophy (DMD) is a severe muscle-wasting disease caused by
mutations in the DMD gene encoding dystrophin, expressed mainly in muscles but also in other …

[HTML][HTML] TRPC3, but not TRPC1, as a good therapeutic target for standalone or complementary treatment of DMD

…, T Larcher, G Toumaniantz, A Lafoux… - Journal of translational …, 2021 - Springer
Background Duchenne muscular dystrophy (DMD) is an X-linked inherited disease caused
by mutations in the gene encoding dystrophin that leads to a severe and ultimately life …

[HTML][HTML] Immunophenotype of a rat model of Duchenne's disease and demonstration of improved muscle strength after anti-CD45RC antibody treatment

LH Ouisse, S Remy, A Lafoux, T Larcher… - Frontiers in …, 2019 - frontiersin.org
Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy
(DMD). Even though they decrease inflammation, they have limited efficacy and are …

[HTML][HTML] Muscle Pathology in Dystrophic Rats and Zebrafish Is Unresponsive to Taurine Treatment, Compared to the mdx Mouse Model for Duchenne Muscular …

JR Terrill, C Huchet, C Le Guiner, A Lafoux, D Caudal… - Metabolites, 2023 - mdpi.com
Inflammation and oxidative stress are strongly implicated in the pathology of Duchenne
muscular dystrophy (DMD), and the sulphur-containing amino acid taurine ameliorates both and …

[HTML][HTML] Skeletal muscle relaxant effect of a standardized extract of Valeriana officinalis L. after acute administration in mice

D Caudal, I Guinobert, A Lafoux, V Bardot… - Journal of traditional and …, 2018 - Elsevier
Valeriana officinalis L. root extracts are traditionally taken for their sedative and anxiolytic
properties and are also used for muscle relaxation. Relaxant effects were clearly observed on …

Pre-clinical study of 21 approved drugs in the mdx mouse

M Carre-Pierrat, A Lafoux, G Tanniou… - Neuromuscular …, 2011 - Elsevier
Duchenne muscular dystrophy, a genetic disease caused by the absence of functional
dystrophin, remains without adequate treatment. Although great hopes are attached to gene and …

[HTML][HTML] Soluble milk protein supplementation with moderate physical activity improves locomotion function in aging rats

A Lafoux, C Baudry, C Bonhomme, P Le Ruyet… - PLoS …, 2016 - journals.plos.org
Aging is associated with a loss of muscle mass and functional capacity. Present study was
designed to compare the impact of specific dairy proteins on muscular function with or without …