Background Mild traumatic brain injury (mTBI) is an all too common occurrence that exacts
significant personal and societal costs. The pathophysiology of mTBI is complex, with reports …

Brain swelling is one of the most robust predictors of outcome following brain injury, including
ischemic, traumatic, hemorrhagic, metabolic or other injury. Depending on the specific type …

Serum biomarkers are promising tools for evaluating patients following traumatic brain injury
(TBI). However, their relationship with diffuse histopathology remains unclear. Additionally, …

Increased intracranial pressure (ICP) associated with traumatic brain injury (TBI) is linked to
increased morbidity. Although our understanding of the pathobiology of TBI has expanded, …

The repercussions of traumatic brain injury (TBI) endure years following the initial insult and
involve chronic impairments/disabilities. Studies indicate that these morbidities stem from …

Glibenclamide (GLY) is the sixth drug tested by the Operation Brain Trauma Therapy (OBTT)
consortium based on substantial pre-clinical evidence of benefit in traumatic brain injury (…

Microglia dynamically interact with neurons influencing the development, structure, and
function of neuronal networks. Recent studies suggest microglia may also influence neuronal …

Traumatic brain injury (TBI) is an extremely complex condition due to heterogeneity in injury
mechanism, underlying conditions, and secondary injury. Pre-clinical and clinical …

Focal adhesion kinase can play unique and opposing roles in regulating the morphology of
differentiating oligodendrocytes - Lafrenaye - 2010 - Journal of Neurochemistry - Wiley …

Interactions between microglia and neuronal components are important for normal CNS
function. They are also associated with neuroinflammation and many pathological processes …