Volumetric muscle loss (VML) injuries are characterized by permanent loss of muscle mass,
structure, and function. Hydrogel biomaterials provide an attractive platform for skeletal …

The fibrous architecture of the extracellular matrix (ECM) is recognized as an integral
regulator of cell function. However, there is an unmet need to develop mechanically robust …

The emergence of synthetic opioids, and especially fentanyl and its analogues, has resulted
in an epidemic of opioid abuse leading to a significant increase in overdose deaths in the …

The fibrous architecture of the extracellular matrix (ECM) is recognized as an integral
regulator of cell function. However, there is an unmet need to develop mechanically robust …

Volumetric muscle loss (VML) can result from trauma and surgery in civilian and military
populations, resulting in irrecoverable functional and cosmetic deficits that cannot be effectively …

Our goal was to understand the impact of regenerative therapies on the functional capacity
of skeletal muscle following volumetric muscle loss (VML) injury. An extensive database …

Current strategies to treat volumetric muscle loss use primarily pedicle or free muscle transfers,
but these grafts fail to adequately regenerate functional tissue. Decellularized soft tissue …

Wounds to the head, neck, and extremities have been estimated to account for ∼84% of
reported combat injuries to military personnel. Volumetric muscle loss (VML), defined as …

In this study, we report the development of a biologically relevant animal model for evaluation
of tissue engineering approaches for repair of volumetric muscle loss (VML) injuries to …

Volumetric muscle loss (VML) injuries, by definition, exceed the endogenous repair capacity
of skeletal muscle resulting in permanent structural and functional deficits. VML injuries …