Background:Vitamin D deficiency and asthma are common at higher latitudes. Although
vitamin D has important immunologic effects, its relation with asthma is unknown. Objective:We …

Rationale: Maternal vitamin D intake during pregnancy has been inversely associated with
asthma symptoms in early childhood. However, no study has examined the relationship …

Epigenetic modifications, including DNA methylation, represent a potential mechanism for
environmental impacts on human disease. Maternal smoking in pregnancy remains an …

Background:Maternal intake of vitamin D in pregnancy is a potentially modifiable but
understudied risk factor for the development of asthma in children. Objective:We investigated …

Rationale: Exposure to particulate air pollution has been related to increased hospitalization
and death, particularly from cardiovascular disease. Lower blood DNA methylation content …

BACKGROUND: Asthma exacerbations, most often caused by respiratory tract infections,
are the leading causes of asthma morbidity and comprise a significant proportion of asthma-…

In the 1960s, the prevalence of asthma and allergic diseases began to increase worldwide.
Currently, the burden of the disease is more than 300 million people affected. We …

Although heredity plays a major role in asthma and in other allergic diseases, mechanisms
underlying the inheritance of these disorders are poorly understood, as is the relative …

Experimental evidence supports a causative role for uric acid in the pathogenesis of
hypertension. Prospective studies have variably adjusted for relevant confounders and have been …

Importance Asthma and wheezing begin early in life, and prenatal vitamin D deficiency has
been variably associated with these disorders in offspring. Objective To determine whether …