Increasing evidence suggests that dysregulation of lipid metabolism is associated with
neurodegeneration in retinal diseases such as age-related macular degeneration and in brain …

Canine adenovirus type 2 vectors (CAV-2) are promising tools to treat global central nervous
system (CNS) disorders because of their preferential transduction of neurons and efficient …

Environmental light has deleterious effects on the outer retina in human retinopathies, such
as ABCA4-related Stargardt’s disease and dry age-related macular degeneration. These …

Among retinal macular diseases, the juvenile recessive Stargardt disease and the age‐related
degenerative disease arise from carbonyl and oxidative stresses ( COS ). Both stresses …

All‐trans‐retinal (atRAL) is a highly reactive carbonyl specie, known for its reactivity on cellular
phosphatidylethanolamine in photoreceptor. It is generated by photoisomerization of 11‐…

Severe deficiency in lysosomal β-glucuronidase (β-glu) enzymatic activity results in
mucopolysaccharidosis (MPS) VII, an orphan disease with symptoms often appearing in early …

Inherited retinal dystrophies are clinically and genetically heterogeneous with significant
number of cases remaining genetically unresolved. We studied a large family from the West …

Corneal transparency is maintained, in part, by specialized fibroblasts called keratocytes,
which reside in the fibrous lamellae of the stroma. Corneal clouding, a condition that impairs …

In retinal pigment epithelium (RPE), RPE65 catalyzes the isomerization of all-trans-retinyl fatty
acid esters to 11-cis-retinol in the visual cycle and controls the rhodopsin regeneration rate…

Background Hematopoietic cells are endowed with very specific biological functions,
including cell motility and immune response. These specific functions are dramatically altered …