User profiles for Aurélien Roux
Aurelien RouxDepartment of Biochemistry, University of Geneva Verified email at unige.ch Cited by 12467 |
Membrane curvature controls dynamin polymerization
The generation of membrane curvature in intracellular traffic involves many proteins that can
curve lipid bilayers. Among these, dynamin-like proteins were shown to deform membranes …
curve lipid bilayers. Among these, dynamin-like proteins were shown to deform membranes …
Nature of curvature coupling of amphiphysin with membranes depends on its bound density
Cells are populated by a vast array of membrane-binding proteins that execute critical functions.
Functions, like signaling and intracellular transport, require the abilities to bind to highly …
Functions, like signaling and intracellular transport, require the abilities to bind to highly …
A minimal system allowing tubulation with molecular motors pulling on giant liposomes
A Roux, G Cappello, J Cartaud… - Proceedings of the …, 2002 - National Acad Sciences
The elucidation of physical and molecular mechanisms by which a membrane tube is
generated from a membrane reservoir is central to the understanding of the structure and …
generated from a membrane reservoir is central to the understanding of the structure and …
Mechanisms of clathrin-mediated endocytosis
M Kaksonen, A Roux - Nature reviews Molecular cell biology, 2018 - nature.com
Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …
GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission
Dynamin, a crucial factor in endocytosis 1 , 2 , 3 , is a member of a family of GTPases that
participates in membrane fission 4 , 5 , 6 . It was initially proposed to act as a machine that …
participates in membrane fission 4 , 5 , 6 . It was initially proposed to act as a machine that …
[PDF][PDF] Relaxation of loaded ESCRT-III spiral springs drives membrane deformation
ESCRT-III is required for lipid membrane remodeling in many cellular processes, from
abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III …
abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III …
Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis
The plasma membrane delimits the cell, and its integrity is essential for cell survival. Lipids
and proteins form domains of distinct composition within the plasma membrane. How …
and proteins form domains of distinct composition within the plasma membrane. How …
Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis
…, I Poser, T Müller-Reichert, S Scheuring, A Roux… - Nature cell …, 2017 - nature.com
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane
fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form …
fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form …
[HTML][HTML] Membrane shape at the edge of the dynamin helix sets location and duration of the fission reaction
The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of
endocytic pits to promote their fission. However, the dynamin mechanism is still debated …
endocytic pits to promote their fission. However, the dynamin mechanism is still debated …
[HTML][HTML] A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats
In endocytosis, scaffolding is one of the mechanisms to create membrane curvature by
moulding the membrane into the spherical shape of the clathrin cage. However, the impact of …
moulding the membrane into the spherical shape of the clathrin cage. However, the impact of …