User profiles for Aurélien Roux

Aurelien Roux

Department of Biochemistry, University of Geneva
Verified email at unige.ch
Cited by 12467

Membrane curvature controls dynamin polymerization

A Roux, G Koster, M Lenz, B Sorre… - Proceedings of the …, 2010 - National Acad Sciences
The generation of membrane curvature in intracellular traffic involves many proteins that can
curve lipid bilayers. Among these, dynamin-like proteins were shown to deform membranes …

Nature of curvature coupling of amphiphysin with membranes depends on its bound density

…, J Prost, P Bassereau, A Roux - Proceedings of the …, 2012 - National Acad Sciences
Cells are populated by a vast array of membrane-binding proteins that execute critical functions.
Functions, like signaling and intracellular transport, require the abilities to bind to highly …

A minimal system allowing tubulation with molecular motors pulling on giant liposomes

A Roux, G Cappello, J Cartaud… - Proceedings of the …, 2002 - National Acad Sciences
The elucidation of physical and molecular mechanisms by which a membrane tube is
generated from a membrane reservoir is central to the understanding of the structure and …

Mechanisms of clathrin-mediated endocytosis

M Kaksonen, A Roux - Nature reviews Molecular cell biology, 2018 - nature.com
Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission

A Roux, K Uyhazi, A Frost, P De Camilli - Nature, 2006 - nature.com
Dynamin, a crucial factor in endocytosis 1 , 2 , 3 , is a member of a family of GTPases that
participates in membrane fission 4 , 5 , 6 . It was initially proposed to act as a machine that …

[PDF][PDF] Relaxation of loaded ESCRT-III spiral springs drives membrane deformation

…, A Colom, F Humbert, M Lenz, S Scheuring, A Roux - Cell, 2015 - cell.com
ESCRT-III is required for lipid membrane remodeling in many cellular processes, from
abscission to viral budding and multi-vesicular body biogenesis. However, how ESCRT-III …

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis

…, N Chiaruttini, I Riezman, H Riezman, A Roux… - Nature cell …, 2012 - nature.com
The plasma membrane delimits the cell, and its integrity is essential for cell survival. Lipids
and proteins form domains of distinct composition within the plasma membrane. How …

Dynamic subunit turnover in ESCRT-III assemblies is regulated by Vps4 to mediate membrane remodelling during cytokinesis

…, I Poser, T Müller-Reichert, S Scheuring, A Roux… - Nature cell …, 2017 - nature.com
The endosomal sorting complex required for transport (ESCRT)-III mediates membrane
fission in fundamental cellular processes, including cytokinesis. ESCRT-III is thought to form …

[HTML][HTML] Membrane shape at the edge of the dynamin helix sets location and duration of the fission reaction

…, F Humbert, L Dinis, M Lenz, G Cappello, A Roux - Cell, 2012 - cell.com
The GTPase dynamin polymerizes into a helical coat that constricts membrane necks of
endocytic pits to promote their fission. However, the dynamin mechanism is still debated …

[HTML][HTML] A balance between membrane elasticity and polymerization energy sets the shape of spherical clathrin coats

…, A Hohendahl, J Manzi, M Lenz, A Roux - Nature …, 2015 - nature.com
In endocytosis, scaffolding is one of the mechanisms to create membrane curvature by
moulding the membrane into the spherical shape of the clathrin cage. However, the impact of …