The human tumor suppressor protein BRCA2 plays a key role in recombinational DNA repair.
BRCA2 recruits RAD51 to sites of DNA damage through interaction with eight conserved …

The breast cancer susceptibility protein, BRCA2, is essential for recombinational DNA repair.
BRCA2 delivers RAD51 to double-stranded DNA (dsDNA) breaks through interaction with …

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian cancers.
Mechanistic insight into the functions of human BRCA2 has been limited by the difficulty …

Recent work, including large-scale genetic and molecular analyses, identified RNA-binding
proteins (RBPs) as major players in the prevention of genome instability. These studies …

Missense variants in the BRCA 2 gene are routinely detected during clinical screening for
pathogenic mutations in patients with a family history of breast and ovarian cancer. These …

The BRCA2 tumor suppressor protein is involved in the maintenance of genome integrity
through its role in homologous recombination. In mitosis, BRCA2 is phosphorylated by Polo-…

We have analyzed the in vitro disassembly of the capsid of the minute virus of mice, and the
stability of capsid chimeras carrying heterologous epitope insertions. Upon heating in a …

BRCA2 tumour-suppressor protein is well known for its role in DNA repair by homologous
recombination (HR); assisting the loading of RAD51 recombinase at DNA double-strand …

The BRCA2 tumor suppressor is a DNA double‐strand break (DSB) repair factor essential
for maintaining genome integrity. BRCA2‐deficient cells spontaneously accumulate DNA‐…

Breast cancer risks conferred by many germline missense variants in the BRCA1 and
BRCA2 genes, often referred to as variants of uncertain significance (VUS), have not been …