Vascular endothelial growth factor a (Vegfa) is essential for blood vessel formation and can
induce activation of numerous signaling effectors in endothelial cells. However, it is unclear …

Differentiation of arteries and veins is essential for the development of a functional circulatory
system. In vertebrate embryos, genetic manipulation of Notch signaling has demonstrated …

Identification of tissue-specific and developmentally active enhancers provides insights into
mechanisms that control gene expression during embryogenesis. However, robust detection …

The acetyltransferases CBP and P300 have been implicated in myogenesis in mouse
immortalized cell lines but these studies focused only on the expression of a handful of myogenic …

NAT10 is an essential enzyme that catalyzes N 4 -acetylcytidine (ac 4 C) in eukaryotic
transfer RNA and 18S ribosomal RNA. Recent studies suggested that rRNA acetylation is …

During development, the vertebrate vasculature undergoes major growth and remodeling.
While the transcriptional cascade underlying blood vessel formation starts to be better …

Manipulation of Notch activity alters neuronal subtype identity in vertebrate neuronal
lineages. Nonetheless, it remains controversial whether Notch activity diversifies cell fate by …

A variety of signaling pathways have been shown to regulate specification of neuronal
subtype identity. However, the mechanisms by which future neurons simultaneously process …

We report the adaptation of RNA tomography, a technique allowing spatially resolved,
genome-wide expression profiling, to a species occupying a key phylogenetic position in …

NAT10 is an essential enzyme that catalyzes the formation of N 4 -acetylcytidine (ac 4 C) in
eukaryotic transfer RNA (tRNA) and 18S ribosomal RNA (rRNA). Recent studies in human …