[HTML][HTML] Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived …
…, B Simon, D Lanneau, A De Thonel… - The Journal of …, 2010 - Am Soc Clin Investig
Myeloid-derived suppressor cells (MDSCs) have been identified in humans and mice as a
population of immature myeloid cells with the ability to suppress T cell activation. They …
population of immature myeloid cells with the ability to suppress T cell activation. They …
Anti-cancer therapeutic approaches based on intracellular and extracellular heat shock proteins
…, M Brunet, AL Joly, AD Thonel… - Current medicinal …, 2007 - ingentaconnect.com
Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist
the proteins in their folding, stability, assembly into multi-protein complexes and transport …
the proteins in their folding, stability, assembly into multi-protein complexes and transport …
Apoptosis versus cell differentiation: role of heat shock proteins HSP90, HSP70 and HSP27
D Lanneau, A de Thonel, S Maurel, C Didelot… - Prion, 2007 - Taylor & Francis
Heat shock proteins HSP27, HSP70 and HSP90 are molecular chaperones whose expression
is increased after many different types of stress. They have a protective function helping …
is increased after many different types of stress. They have a protective function helping …
Restoring anticancer immune response by targeting tumor-derived exosomes with a HSP70 peptide aptamer
…, F Lirussi, F Ghiringhelli, A de Thonel… - Journal of the …, 2016 - academic.oup.com
Background: Exosomes, via heat shock protein 70 (HSP70) expressed in their membrane,
are able to interact with the toll-like receptor 2 (TLR2) on myeloid-derived suppressive cells (…
are able to interact with the toll-like receptor 2 (TLR2) on myeloid-derived suppressive cells (…
[HTML][HTML] HSP90 and HSP70: implication in inflammation processes and therapeutic approaches for myeloproliferative neoplasms
M Sevin, F Girodon, C Garrido, A De Thonel - Mediators of …, 2015 - hindawi.com
Myeloproliferative neoplasms (MPN) are clonal stem cell disorders that lead to the excessive
production of one or more blood cell lineages. It has been reported that, in most MPN, …
production of one or more blood cell lineages. It has been reported that, in most MPN, …
[PDF][PDF] Binding and phosphorylation of par-4 by akt is essential for cancer cell survival
Activation of the PI3K-Akt pathway by loss of tumor suppressor PTEN (phosphatase and
tensin homolog deleted on chromosome 10) function, increased growth factor signaling, or …
tensin homolog deleted on chromosome 10) function, increased growth factor signaling, or …
Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of
HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), …
HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), …
Peptides and aptamers targeting HSP70: a novel approach for anticancer chemotherapy
AL Rérole, J Gobbo, A De Thonel, E Schmitt… - Cancer research, 2011 - AACR
The inhibition of heat shock protein 70 (HSP70) is an emerging strategy in cancer therapy.
Unfortunately, no specific inhibitors are clinically available. By yeast two-hybrid screening, we …
Unfortunately, no specific inhibitors are clinically available. By yeast two-hybrid screening, we …
Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy
Background & Aims Patients with colorectal tumors with microsatellite instability (MSI) have
better prognoses than patients with tumors without MSI, but have a poor response to 5-…
better prognoses than patients with tumors without MSI, but have a poor response to 5-…
Transcriptional regulation of small HSP—HSF1 and beyond
A de Thonel, A Le Mouël, V Mezger - … journal of biochemistry & cell biology, 2012 - Elsevier
The members of the small heat shock protein (sHSP) family are molecular chaperones that
play major roles in development, stress responses, and diseases, and have been envisioned …
play major roles in development, stress responses, and diseases, and have been envisioned …