The causative agent of the coronavirus disease 2019 (COVID-19) pandemic, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected millions and killed hundreds …

Many methods allow us to extract biological activities from omics data using information from
prior knowledge resources, reducing the dimensionality for increased statistical power and …

Bone marrow fibrosis (BMF) develops in various hematological and non-hematological
conditions and is a central pathological feature of myelofibrosis. Effective cell-targeted …

The bioenergetics and molecular determinants of the metabolic response to mitochondrial
dysfunction are incompletely understood, in part due to a lack of appropriate isogenic cellular …

Multi‐omics datasets can provide molecular insights beyond the sum of individual omics.
Various tools have been recently developed to integrate such datasets, but there are limited …

Biological processes are regulated by intermolecular interactions and chemical modifications
that do not affect protein levels, thus escaping detection in classical proteomic screens. We …

The growing availability of single-cell data, especially transcriptomics, has sparked an
increased interest in the inference of cell-cell communication. Many computational tools were …

We need to effectively combine the knowledge from surging literature with complex datasets
to propose mechanistic models of SARS‐CoV‐2 infection, improving data interpretation and …

BACKGROUND: SGLT2 (sodium-glucose cotransporter 2) inhibitors (SGLT2i) can protect the
kidneys and heart, but the underlying mechanism remains poorly understood. METHODS: …

Metabolic reprogramming is critical for tumor initiation and progression. However, the exact
impact of specific metabolic changes on cancer progression is poorly understood. Here, we …