In mammals, circadian oscillators reside not only in the suprachiasmatic nucleus of the brain,
which harbors the central pacemaker, but also in most peripheral tissues. Here, we show …

The treatment of cultured rat-1 fibroblasts or H35 hepatoma cells with high concentrations of
serum induces the circadian expression of various genes whose transcription also oscillates …

In mammals, all overt circadian rhythms are thought to be coordinated by a central pacemaker
residing in the hypothalamic suprachiasmatic nucleus (SCN) [1]. The phase of this …

For many years, neurons of the suprachiasmatic nucleus (SCN) in the hypothalamus were
thought to contain the unique mammalian clock controlling circadian rhythmicity of peripheral …

Transcription factor recruitment to genomic sites of action is primarily due to direct protein:DNA
interactions. The subsequent recruitment of coregulatory complexes leads to either …

Pioneer factors are transcription factors with the unique ability to initiate opening of closed
chromatin. The stability of cell identity relies on robust mechanisms that maintain the …

The anterior and intermediate lobes of the pituitary gland derive from the surface ectoderm.
They provide a simple system to assess mechanisms of developmental identity established …

Pioneer transcription factors establish new cell-fate competence by triggering chromatin
remodeling. However, many features of pioneer action, such as their kinetics and stability, …

Pioneer transcription factors are characterized by having the unique property of enabling the
opening of closed chromatin sites, for implementation of cell fates. We previously found that …

Background DAVID syndrome is a rare condition combining anterior pituitary hormone
deficiency with common variable immunodeficiency. NFKB2 mutations have recently been …