Repeat families within genomes are often maintained with similar sequences. Traditionally,
this has been explained by concerted evolution, where repeats in an array evolve “in concert…

Organisms maintain ribosomal RNA gene repeats (rDNA) at stable copy numbers by
recombination; the loss of repeats results in gene amplification. Here we report a mechanism of …

Chytridiomycosis is a recently identified fungal disease associated with global population
declines of frogs. Although the fungus, Batrachochytrium dendrobatidis, is considered an …

This study attempts to resolve relationships among and within the four basal arthropod lineages
(Pancrustacea, Myriapoda, Euchelicerata, Pycnogonida) and to assess the widespread …

In eukaryotes, the ribosomal DNA (rDNA) consists of long tandem repeat arrays. These
repeated genes are unstable because homologous recombination between them results in copy …

The short arms of the five acrocentric human chromosomes harbor sequences that direct
the assembly and function of the nucleolus, one of the key functional domains of the nucleus, …

The yeast Saccharomyces cerevisiae is a powerful model system to understand the molecular
basis of aging. It has been known for over 50 years that yeast cells have a finite replicative …

Genomic instability is a conserved factor in lifespan reduction, although the molecular
mechanism is not known [1]. Studies in the yeast Saccharomyces cerevisiae over the past 20 …

Structural features of genomes, including the three-dimensional arrangement of DNA in the
nucleus, are increasingly seen as key contributors to the regulation of gene expression. …

Ribosomal RNA gene repeats (rDNA) encode ribosomal RNA, a major component of ribosomes.
Ribosome biogenesis is central to cellular metabolic regulation, and several diseases …