Discovery of novel gain-of-function mutations guided by structure-based deep learning

R Shroff, AW Cole, DJ Diaz, BR Morrow… - ACS synthetic …, 2020 - ACS Publications
Despite the promise of deep learning accelerated protein engineering, examples of such
improved proteins are scarce. Here we report that a 3D convolutional neural network trained to …

[HTML][HTML] Cellular reagents for diagnostics and synthetic biology

S Bhadra, A Pothukuchy, R Shroff, AW Cole, M Byrom… - PLoS …, 2018 - journals.plos.org
We have found that the overproduction of enzymes in bacteria followed by their lyophilization
leads to 'cellular reagents' that can be directly used to carry out numerous molecular …

Heat adaptation of phage T7 under an extended genetic code

AW Cole, SD Tran, AD Ellington - Virus Evolution, 2021 - academic.oup.com
While bacteriophages have previously been used as a model system to understand thermal
adaptation, most adapted genomes observed to date contain very few modifications and …

A structure-based deep learning framework for protein engineering

R Shroff, AW Cole, BR Morrow, DJ Diaz, I Donnell… - BioRxiv, 2019 - biorxiv.org
While deep learning methods exist to guide protein optimization, examples of novel proteins
generated with these techniques require a priori mutational data. Here we report a 3D …

Experimental and data collection methods for a large-scale smart grid deployment: Methods and first results

…, AL Beck, K Nagasawa, RL Fares, WJ Cole… - Energy, 2014 - Elsevier
… ”) project are located on the site of Austin's former municipal airport, close to central Austin.
The homes that are part of the Duke project are located throughout the greater Austin area. …

The IntCal20 Northern Hemisphere radiocarbon age calibration curve (0–55 cal kBP)

PJ Reimer, WEN Austin, E Bard, A Bayliss… - …, 2020 - cambridge.org
Radiocarbon (14C) ages cannot provide absolutely dated chronologies for archaeological
or paleoenvironmental studies directly but must be converted to calendar age equivalents …

Myth Makers and the Early Years of the Carmel Forest Theatre

W Cole - Theatre West, 1990 - brill.com
… at the Bohemian Grove, the little theatre movement was under w~y in other parts of the
country, and Sterling, Mrs. Austin, and Williams began to talk about founding an art theatre in …

[PDF][PDF] University of Texas at Austin

G Perez, WJ Cole, M Baldea, TF Edgar - 2014 - aceee.org
… In this paper, we report on the development of ROMs for 41 physical houses in Austin, Texas,
using smart meter data. These models require outdoor dry bulb temperature, thermostat set …

Journal of the Society of Arts, Vol. 19, no. 943

AS Cole, JA Franklin, J Booth, W Austin… - The Journal of the …, 1870 - JSTOR
1. The many remnants of Greek and Roman mosaic, more than two thousand years old,
prove the possibility of obtaining by one method at least, permanent decoration. Although …

Journal of the Society for Arts, Vol. 22, no. 1114

…, HH Cole, C Le Neve Foster, W Austin… - The Journal of the …, 1874 - JSTOR
In 1864, to Sir Rowland Hill, KCB," for his great service to Arts, Manufactures, and Commerce,
in the creation of the penny postage, and for his other reforms in the postal system of this …