There is a critical need for adjuvants that can safely elicit potent and durable T cell-based
immunity to intracellular pathogens. Here, we report that parenteral vaccination with a …

Induction of protective mucosal T cell memory remains a formidable challenge to vaccinologists.
Using a combination adjuvant strategy that elicits potent CD8 and CD4 T cell responses…

Eliciting durable and protective T cell-mediated immunity in the respiratory mucosa remains
a significant challenge. Polylactic-co-glycolic acid (PLGA)-based cationic pathogen-like …

The development of T cell-based subunit protein vaccines against diseases such as
tuberculosis and malaria remains a challenge for immunologists. Here, we have identified a …

Abstract Development of T-cell-based subunit protein vaccines against diseases, such as
AIDS, tuberculosis and malaria remains a challenge for immunologists. Here, we have …

Here, we report that a carbomer-based adjuvant, Adjuplex® (ADJ), stimulated robust CD8 T-cell
responses to subunit antigens by modulating multiple steps in the cytosolic pathway of …

Respiratory epithelial cells (RECs) express Toll-like receptors (TLRs), produce both pro-inflammatory
and anti-inflammatory molecules and function as immunological rheostats in the …

T cell-mediated immunity (CMI) can provide long-lived protection following parenteral
immunization, but eliciting durable and protective CMI in the mucosa remains a significant …

… In the autumn experiment the control toads showed only moderate increases in body mass,
and fat and glycogen constituted most of the gain. Only three out of 15 toads gained in body …

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