Chronic stress impairs learning and memory in humans and rodents and disrupts long-term
potentiation (LTP) in animal models. These effects are associated with structural changes in …

BACKGROUND: Early-life emotional stress may be associated with affective and cognitive
disorders later in life, yet satisfactory animal models for studying the underlying mechanisms …

The antidepressants, reboxetine and citalopram, were used in conjunction with voluntary
physical exercise (wheel running) in order to assess the contribution of noradrenergic and …

Memory and related cognitive functions are progressively impaired in a subgroup of
individuals experiencing childhood adversity and stress. However, it is not possible to identify …

Biallelic pathogenic variants in PLPBP (formerly called PROSC) have recently been shown
to cause a novel form of vitamin B6-dependent epilepsy, the pathophysiological basis of …

Previous studies have shown that running exercise, either alone or in combination with
antidepressant treatment, results in increased hippocampal BDNF levels. Nitric oxide (NO) is an …

Physical exercise is a powerful modulator of learning and memory. Mechanisms underlying
the cognitive benefits of exercise are well documented in adult rodents. Exercise studies …

Since the discovery of the genetic basis of Rett syndrome in 1999, our understanding has
grown considerably both in the scientific and the clinical realms. In the last two decades, we …

In humans, early-life adversity is associated with impairments in learning and memory that
may emerge later in life. In rodent models, early-life adversity directly impacts hippocampal …

Epigenetic regulation of transcription is gaining increasing importance in the study of neurobiology.
The advent of sequencing technology has enabled the study of this regulation across …