A primary goal of systems biology is to understand the design principles of the transcription
networks that govern the timing of gene expression 1 , 2 , 3 , 4 , 5 . Here we measured …

Biological systems that perform multiple tasks face a fundamental trade-off: A given phenotype
cannot be optimal at all tasks. Here we ask how trade-offs affect the range of phenotypes …

Cell elongation and polarization are basic morphogenetic responses to extracellular matrix
adhesion. We demonstrate here that human cultured fibroblasts readily polarize when plated …

Latency and ongoing replication 1 have both been proposed to explain the drug-insensitive
human immunodeficiency virus (HIV) reservoir maintained during antiretroviral therapy. …

Cells remove proteins by two processes: degradation and dilution due to cell growth. The
balance between these basic processes is poorly understood. We addressed this by …

10.7554/eLife.12432.001 Nervous system maps are of critical importance for understanding
how nervous systems develop and function. We systematically map here all cholinergic …

Cell communication within tissues is mediated by multiple paracrine signals including
growth factors, which control cell survival and proliferation. Cells and the growth factors they …

Recent studies suggest that certain cellular sensory systems display fold-change detection (FCD):
a response whose entire shape, including amplitude and duration, depends only on …

The tumor microenvironment (TME) is comprised of non-malignant cells that interact with
each other and with cancer cells, critically impacting cancer biology. The TME is complex, and …

Tumors are supported by cancer-associated fibroblasts (CAFs). CAFs are heterogeneous
and carry out distinct cancer-associated functions. Understanding the full repertoire of CAFs …