Stiffness and actomyosin contractility are intrinsic mechanical properties of animal cells
required for the shaping of tissues. However, whether tissue stem cells (SCs) and progenitors …

Lamins are intermediate filament proteins of type V constituting a nuclear lamina or
filamentous meshwork which lines the nucleoplasmic side of the inner nuclear membrane. This …

Vinculin, a mechanotransducer associated with both adherens junctions (AJs) and focal
adhesions (FAs), plays a central role in force transmission through cell-cell and cell-substratum …

Lamin A protein, encoded by the LMNA gene, belongs to the type V intermediate filament
protein family and is a major nuclear protein component of higher metazoan organisms, …

Stem cells have been shown to play an important role in regenerative medicine due to their
proliferative and differentiation potential. The challenge, however, lies in regulating and …

Background Dilated Cardiomyopathy (DCM) is one of the most commonly encountered heart
diseases reported globally. It is characterized by enlarged ventricles with impaired systolic …

Generating high-quality electron microscopy images of the skin and keratinocytes can be
challenging. Here we describe a simple protocol for scanning electron microscopy (SEM) of …

Mutations in lamin A have been reported to be associated with over 16 human diseases
including dilated cardiomyopathy (DCM). We have focused on three such DCM causing mutants …

Shodhganga@INFLIBNET: Effects of lamin a mutations in nuclear morphology function and
mechanics A plausible link with dilated cardiomyopathy Skip navigation DSpace logo Home Browse …

Glioblastoma multiforme (GBM) is an aggressive cancer without currently effective therapies.
Radiation and temozolomide (radio/TMZ) resistance are major contributors to cancer …